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Boosting CAR-T cell therapies from under the

Boosting CAR-T cell therapies from under the
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Tufts University , United States , Spaulding Rehabilitation Hospital , University Of Massachusetts Medical School , Boston University , Massachusetts Institute Of Technology , Miguel Sobral , Kwasi Adu Berchie , Robertp Pinkas , David Zhang , Joshua Brockman , Yutong Liu , David Mooney , Yoav Binenbaum , Donald Ingber , Dave Mooney , Benjamin Boettner , Drug Administration , Farber Cancer Institute , Beth Israel Deaconess Medical Center , University Of Wisconsin , Arts Sciences , Harvard Johna Paulson School Of Engineering , Wyss Institute At Harvard University , National Institutes , Method Of Research ,

Fast on-demand multi-material multi-nozzle 3D printing in a fraction of the time

3D printing is revolutionizing the manufacturing industry by allowing people to create without the need for expensive machinery and raw materials ....

United States , Mark Skylar Scott , Jennifera Lewis , Donald Ingber , Jochen Mueller , Wyss Institute , Johna Paulson School Of Engineering , Wyss Institute At Harvard University , Vascular Biology Program At Boston Children Hospital , Harvard Wyss Institute For Biologically Inspired Engineering , Biologically Inspired Engineering , Applied Sciences , Research Associate , Research Fellow , Core Faculty Member , Wyss Professor , Wyss Founding Director , Judah Folkman Professor , Vascular Biology , Harvard Medical School , Vascular Biology Program , Boston Children ,

Expanding a lymph node, boosting a vaccine

For the first time, researchers from the Wyss Institute for Biologically Inspired Engineering at Harvard University, Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), and Genentech<u>, a member of the Roche Group,</u> found a way to enhance and extend LN expansion, and study how this phenomenon affects both the immune system and efficacy of vaccinations against tumors. While the oversized LNs maintained a normal tissue organization, they displayed altered mechanical features and hosted higher numbers of various immune cell types that commonly are involved in immune responses against pathogens and cancers. Importantly, “jump-starting” lymph node expansion prior to administering a traditional vaccine against a melanoma-specific model antigen led to more effective and sustained anti-tumor responses in mice.  ....

Massachusetts Institute Of Technology , United States , Tufts University , Spaulding Rehabilitation Hospital , University Of Massachusetts Medical School , Boston University , Benjamin Freedman , Katherine Williams , Maxence Dellacherie , Shannon Turley , Christina Tringides , Hamza Ijaz , Joel Gutierrez Estupinan , Giovanni Bovone , Alberto Elosegui Artola , Benjamin Boettner , Shawn Kang , Miguel Sobral , Robertp Pinkas , Alexander Najibi , Donald Ingber , David Mooney , Harvard Johna Paulson School Of Engineering , Farber Cancer Institute , Arts Sciences , National Institutes Of Health Cancer Institute ,

Durable lymph-node expansion improves vaccine responses against tumors

Each one of us has around 600 lymph nodes (LNs) – small, bean-shaped organs that house various types of blood cells and filter lymph fluid – scattered throughout our bodies. ....

United States , Maxence Dellacherie , Hamza Ijaz , Joel Gutierrez Estupinan , Giovanni Bovone , Robertp Pinkas , David Mooney , Shannon Turley , Alberto Elosegui Artola , Donald Ingber , Christina Tringides , Miguel Sobral , Benjamin Freedman , Shawn Kang , Alexander Najibi , Katherine Williams , Harvard Johna Paulson School Of Engineering , Wyss Institute , National Institutes Of Health Cancer Institute , Roche Group , Wyss Institute Founding Core Faculty , Biologically Inspired Engineering , Harvard University , Harvard John , Applied Sciences , Nature Biomedical ,

A new glue, potentially also for you

<p>Hydrogels are already used in clinical practice for the delivery of drugs, and as lenses, bone cement, wound dressings, 3D scaffolds in tissue engineering and other applications. However, bonding different hydrogel polymers to one another has remained a challenge; yet it could enable numerous new applications. Now, Harvard Wyss and SEAS researchers pioneered a new method that uses a thin film of chitosan, a fibrous sugar-based material derived from the processed outer skeletons of shellfish, to make different hydrogels instantaneously and strongly stick to each other. They used their approach to locally protect and cool tissues, seal vascular injuries, and prevent unwanted “surgical adhesions” of internal body surfaces. </p>
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University Of Massachusetts Medical School , United States , Massachusetts Institute Of Technology , Spaulding Rehabilitation Hospital , Tufts University , Boston University , Dave Mooney , Juan Cintron Cruz , Benjamin Boettner , Daniel Kent , David Mooney , Robertp Pinkas , Mathew Lee , Phoebe Kwon , James Weaver , Donald Ingber , Benjamin Freedman , Haley Jeffers , Wyss Institute , National Institutes Of Health Institute On , Proceedings Of The National Academy Science , Founding Wyss Institute Core Faculty , Farber Cancer Institute , Method Of Research , Wyss Institute At Harvard University , Wyss Research ,