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Boosting CAR-T cell therapies from under the skin

CAR-T cell therapies are transforming the treatment of previously incurable blood cancers, but a large proportion of patients still responds only poorly or not at all to them, calling for new strategies to overcome this challenge. Now, a research team has developed a simple intervention in the form of a biodegradable scaffold material called T-cell enhancing scaffolds (TES) that can be locally injected under the skin and used to restimulate CAR-T cells after their administration. This increased their therapeutic efficacy and significantly curbed tumor growth and prolonged animal survival in an aggressive mouse lymphoma model. ....

United States , Miguel Sobral , Robertp Pinkas , Yoav Binenbaum , Yutong Liu , Donald Ingber , Dave Mooney , David Mooney , David Zhang , Joshua Brockman , Kwasi Adu Berchie , Drug Administration , Harvard Johna Paulson School Of Engineering , Wyss Institute At Harvard University , National Institutes Of Health , University Of Wisconsin , Wyss Institute , Biologically Inspired Engineering , Harvard University , Harvard John , Applied Sciences , Nature Biomedical , Wyss Founding Core Faculty , Family Professor , Postdoctoral Fellow , Assistant Professor ,

MAKING THEIR MARK - Yutong Liu: International Students

Crossing an ocean to study in another country can be tough.
Meet one former international student who says at first, it was a real struggle.
Now, she's caring for others in Thunder Bay, both as a healthcare worker, and as the organizer of an annual event that brings international students together. ....

Thunder Bay , Yutong Liu , International Students ,