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Expanding a lymph node, boosting a vaccine

For the first time, researchers from the Wyss Institute for Biologically Inspired Engineering at Harvard University, Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), and Genentech<u>, a member of the Roche Group,</u> found a way to enhance and extend LN expansion, and study how this phenomenon affects both the immune system and efficacy of vaccinations against tumors. While the oversized LNs maintained a normal tissue organization, they displayed altered mechanical features and hosted higher numbers of various immune cell types that commonly are involved in immune responses against pathogens and cancers. Importantly, “jump-starting” lymph node expansion prior to administering a traditional vaccine against a melanoma-specific model antigen led to more effective and sustained anti-tumor responses in mice.  ....

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Lymph Node Expansion Enhances Vaccine Efficacy

Lymph Node Expansion Enhances Vaccine Efficacy
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Durable lymph-node expansion improves vaccine responses against tumors

Each one of us has around 600 lymph nodes (LNs) – small, bean-shaped organs that house various types of blood cells and filter lymph fluid – scattered throughout our bodies. ....

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$63M grant funds OK'd to bring cancer research, treatment to Texas

The oversight committee of the Cancer Prevention and Research Institute of Texas (CPRIT) approved $63 million in grant allocation Wednesday to help "bring innovative researchers and companies to Texas." ....

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$63M grant funds OK'd to bring cancer research, treatment to Texas

The oversight committee of the Cancer Prevention and Research Institute of Texas (CPRIT) approved $63 million in grant allocation Wednesday to help "bring innovative researchers and companies to Texas." ....

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