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Boosting CAR-T cell therapies from under the

Boosting CAR-T cell therapies from under the
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Tufts University , United States , Spaulding Rehabilitation Hospital , University Of Massachusetts Medical School , Boston University , Massachusetts Institute Of Technology , Miguel Sobral , Kwasi Adu Berchie , Robertp Pinkas , David Zhang , Joshua Brockman , Yutong Liu , David Mooney , Yoav Binenbaum , Donald Ingber , Dave Mooney , Benjamin Boettner , Drug Administration , Farber Cancer Institute , Beth Israel Deaconess Medical Center , University Of Wisconsin , Arts Sciences , Harvard Johna Paulson School Of Engineering , Wyss Institute At Harvard University , National Institutes , Method Of Research ,

Microfluidic Organ Chip Models Human Cervix, Boosts Women's Health

Microfluidic Organ Chip Models Human Cervix, Boosts Women's Health
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Expanding a lymph node, boosting a vaccine

For the first time, researchers from the Wyss Institute for Biologically Inspired Engineering at Harvard University, Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), and Genentech<u>, a member of the Roche Group,</u> found a way to enhance and extend LN expansion, and study how this phenomenon affects both the immune system and efficacy of vaccinations against tumors. While the oversized LNs maintained a normal tissue organization, they displayed altered mechanical features and hosted higher numbers of various immune cell types that commonly are involved in immune responses against pathogens and cancers. Importantly, “jump-starting” lymph node expansion prior to administering a traditional vaccine against a melanoma-specific model antigen led to more effective and sustained anti-tumor responses in mice.  ....

Massachusetts Institute Of Technology , United States , Tufts University , Spaulding Rehabilitation Hospital , University Of Massachusetts Medical School , Boston University , Benjamin Freedman , Katherine Williams , Maxence Dellacherie , Shannon Turley , Christina Tringides , Hamza Ijaz , Joel Gutierrez Estupinan , Giovanni Bovone , Alberto Elosegui Artola , Benjamin Boettner , Shawn Kang , Miguel Sobral , Robertp Pinkas , Alexander Najibi , Donald Ingber , David Mooney , Harvard Johna Paulson School Of Engineering , Farber Cancer Institute , Arts Sciences , National Institutes Of Health Cancer Institute ,

Lymph Node Expansion Enhances Vaccine Efficacy

Lymph Node Expansion Enhances Vaccine Efficacy
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United States , Katherine Williams , Shannon Turley , Maxence Dellacherie , Benjamin Freedman , Alberto Elosegui Artola , Benjamin Boettner , Joel Gutierrez Estupinan , Giovanni Bovone , Christina Tringides , Hamza Ijaz , Miguel Sobral , Shawn Kang , Robertp Pinkas , Alexander Najibi , Donald Ingber , David Mooney , Wyss Institute , Roche Group , Wyss Institute Founding Core Faculty , National Institutes Of Health Cancer Institute , Harvard Johna Paulson School Of Engineering , Biologically Inspired Engineering , Harvard University , Harvard John , Applied Sciences ,

Innovative Adhesive: Potential Game-Changer for Consumers

Innovative Adhesive: Potential Game-Changer for Consumers
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United States , Robertp Pinkas , Benjamin Boettner , David Mooney , Mathew Lee , James Weaver , Dave Mooney , Daniel Kent , Donald Ingber , Juan Cintron Cruz , Phoebe Kwon , Haley Jeffers , Wyss Research Associate Benjamin Freedman , National Institutes Of Health Institute On , Wyss Institute At Harvard University , Wyss Institute , Founding Wyss Institute Core Faculty , Proceedings Of The National Academy Science , Harvard Johna Paulson School Of Engineering , Research Scholar , Biologically Inspired Engineering , Harvard University , Harvard John , Applied Sciences , National Academy , Family Professor ,