Live Breaking News & Updates on Wyss Founding Director|Page 2

Stay updated with breaking news from Wyss founding director. Get real-time updates on events, politics, business, and more. Visit us for reliable news and exclusive interviews.

Human Lung Chip Leveraged to Faithfully Model Radiation-induced Lung Injury

Human life-like in vitro model of radiation damage sustained to the lung opens an unprecedented window into the early disease process, and opportunities for drug development ....

United States , Queeny Dasgupta , Donald Ingber , Drug Administration , Network Model For Causality , Wyss Institute , Harvard Johna Paulson School Of Engineering , Harvard Medical School , Nature Communications , Biologically Inspired Engineering , Harvard University , Boston Children , Wyss Founding Director , Lung Alveolus Chip , Lung Chip , Organ Chip , Folkman Professor , Vascular Biology , Wyss Professor , Bioinspired Engineering , Harvard John , Lung Alveolus , Postdoctoral Fellow , Systemic Bio , Organ Chips ,

Human Lung Chip leveraged to faithfully model

<p>Researchers have developed a human <em>in vitro</em> model that closely mimics the complexities of radiation-induced lung injury (RILI) and radiation dose sensitivity of the human lung. Using a previously developed microfluidic human Lung Alveolus Chip lined by human lung alveolar epithelial cells interfaced with lung capillary cells to recreate the alveolar-capillary interface <em>in vitro</em>, the researchers recapitulated many of the hallmarks of RILI, including radiation-induced DNA damage in lung tissue, cell-specific changes in gene expression, inflammation, and injury to both the lung epithelial cells and blood vessel-lining endothelial cells. By also evaluating the potential of two drugs to suppress the effects of acute RILI, the researchers demonstrated their model’s capabilities as an advanced, human-relevant, preclinical, drug discovery platform.</p>
....

Boston University , United States , Massachusetts Institute Of Technology , Tufts University , University Of Massachusetts Medical School , Spaulding Rehabilitation Hospital , Donald Ingber , Benjamin Boettner , Robert Mannix , Amanda Jiang , Amy Wen , Sean Hall , Emilia Javorsky , Queeny Dasgupta , Farber Cancer Institute , Drug Administration , Method Of Research , Arts Sciences , Network Model For Causality , Harvard Johna Paulson School Of Engineering , Wyss Institute , Wyss Institute At Harvard University , Nature Communications , Beth Israel Deaconess Medical Center , Biologically Inspired Engineering , Harvard University ,

Adding immunity to human kidney-on-a-chip adv

T cell bispecific antibodies (TCBs) are an emerging class of immunotherapeutics with several TCBs approved by the FDA for the treatment of leukemias, lymphomas, and myelomas. TCBs label tumor cells with one of their ends, and attract immune cells with another end to coerce them into tumor cell killing. However, one major challenge in the development of TCBs are “on-target, off-tumor” toxicities at sites in the body that also express TCB-targeted antigens. A new collaboration of Jennifer Lewis’ group and researchers from the Roche Innovation Centers in Switzerland and Germany now created an immune-infiltrated human kidney organoid-on-chip model that allows kidney toxicity of TCBs. ....

United States , Spaulding Rehabilitation Hospital , Tufts University , Massachusetts Institute Of Technology , University Of Massachusetts Medical School , Boston University , Benjamin Boettner , Antje Christine Walz , Mariana Mata , Ken Hiratsuka , Jennifer Lewis , Katharina Kroll , Donald Ingber , Virginie Micallef , Kimberly Homan , Joseph Bonventre , Marcel Gruber , Jennifer Lewi , Annie Moisan , Ryuji Morizane , Alejandro Carpy , Method Of Research , Harvard Medical School , Beth Israel Deaconess Medical Center , Proceedings Of The National Academy Sciences , Roche Innovation Center Basel ,

Adding immunity to human kidney-on-a-chip adv

Adding immunity to human kidney-on-a-chip adv
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

United States , Massachusetts Institute Of Technology , University Of Massachusetts Medical School , Spaulding Rehabilitation Hospital , Boston University , Tufts University , Kimberly Homan , Jennifer Lewis , Katharina Kroll , Jennifer Lewi , Virginie Micallef , Joseph Bonventre , Mariana Mata , Marcel Gruber , Annie Moisan , Alejandro Carpy , Donald Ingber , Antje Christine Walz , Benjamin Boettner , Ken Hiratsuka , Ryuji Morizane , International Foundation Of Ethical Research , Beth Israel Deaconess Medical Center , Roche Innovation Center Basel , Harvard Medical School , National Center ,

Moving the needle on monitoring skin cancer

Moving the needle on monitoring skin cancer
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Tufts University , United States , Boston University , Spaulding Rehabilitation Hospital , University Of Massachusetts Medical School , Massachusetts Institute Of Technology , David Walt , Michael Lewandowski , Mariana Alonso , Alexander Cryer , Daniel Dahis , Rushdy Ahmad , Natalie Artzi , Haim Azhari , Michelle Dion , Donald Ingber , Benjamin Boettner , Pere Dosta , Research Scientist , Principal Research Scientist , Method Of Research , Technion Israel Institute Of Technology , Binational Science Fund , Institute For Medical Engineering , Wyss Institute At Harvard University , Farber Cancer Institute ,