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Boosting CAR-T cell therapies from under the

Boosting CAR-T cell therapies from under the skin

CAR-T cell therapies are transforming the treatment of previously incurable blood cancers, but a large proportion of patients still responds only poorly or not at all to them, calling for new strategies to overcome this challenge. Now, a research team has developed a simple intervention in the form of a biodegradable scaffold material called T-cell enhancing scaffolds (TES) that can be locally injected under the skin and used to restimulate CAR-T cells after their administration. This increased their therapeutic efficacy and significantly curbed tumor growth and prolonged animal survival in an aggressive mouse lymphoma model.

Expanding a lymph node, boosting a vaccine

For the first time, researchers from the&nbsp;Wyss Institute for Biologically Inspired Engineering at Harvard University,&nbsp;Harvard John A. Paulson School of Engineering and Applied Sciences&nbsp;(SEAS), and&nbsp;Genentech<u>, a member of the Roche Group,</u>&nbsp;found a way to enhance and extend LN expansion, and study how this phenomenon affects both the immune system and efficacy of vaccinations against tumors. While the oversized LNs maintained a normal tissue organization, they displayed altered&nbsp;mechanical features&nbsp;and hosted higher numbers of various immune cell types that commonly are involved in immune responses against pathogens and cancers. Importantly, &ldquo;jump-starting&rdquo; lymph node expansion prior to administering a traditional vaccine against a melanoma-specific model antigen led to more effective and sustained anti-tumor responses in mice.&nbsp;

Lymph Node Expansion Enhances Vaccine Efficacy

Durable lymph-node expansion improves vaccine responses against tumors

Each one of us has around 600 lymph nodes (LNs) – small, bean-shaped organs that house various types of blood cells and filter lymph fluid – scattered throughout our bodies.