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Boosting CAR-T cell therapies from under the

Boosting CAR-T cell therapies from under the
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Tufts University , United States , Spaulding Rehabilitation Hospital , University Of Massachusetts Medical School , Boston University , Massachusetts Institute Of Technology , Miguel Sobral , Kwasi Adu Berchie , Robertp Pinkas , David Zhang , Joshua Brockman , Yutong Liu , David Mooney , Yoav Binenbaum , Donald Ingber , Dave Mooney , Benjamin Boettner , Drug Administration , Farber Cancer Institute , Beth Israel Deaconess Medical Center , University Of Wisconsin , Arts Sciences , Harvard Johna Paulson School Of Engineering , Wyss Institute At Harvard University , National Institutes , Method Of Research ,

Boosting CAR-T cell therapies from under the skin

CAR-T cell therapies are transforming the treatment of previously incurable blood cancers, but a large proportion of patients still responds only poorly or not at all to them, calling for new strategies to overcome this challenge. Now, a research team has developed a simple intervention in the form of a biodegradable scaffold material called T-cell enhancing scaffolds (TES) that can be locally injected under the skin and used to restimulate CAR-T cells after their administration. This increased their therapeutic efficacy and significantly curbed tumor growth and prolonged animal survival in an aggressive mouse lymphoma model. ....

United States , Miguel Sobral , Robertp Pinkas , Yoav Binenbaum , Yutong Liu , Donald Ingber , Dave Mooney , David Mooney , David Zhang , Joshua Brockman , Kwasi Adu Berchie , Drug Administration , Harvard Johna Paulson School Of Engineering , Wyss Institute At Harvard University , National Institutes Of Health , University Of Wisconsin , Wyss Institute , Biologically Inspired Engineering , Harvard University , Harvard John , Applied Sciences , Nature Biomedical , Wyss Founding Core Faculty , Family Professor , Postdoctoral Fellow , Assistant Professor ,

Expanding a lymph node, boosting a vaccine

For the first time, researchers from the Wyss Institute for Biologically Inspired Engineering at Harvard University, Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), and Genentech<u>, a member of the Roche Group,</u> found a way to enhance and extend LN expansion, and study how this phenomenon affects both the immune system and efficacy of vaccinations against tumors. While the oversized LNs maintained a normal tissue organization, they displayed altered mechanical features and hosted higher numbers of various immune cell types that commonly are involved in immune responses against pathogens and cancers. Importantly, “jump-starting” lymph node expansion prior to administering a traditional vaccine against a melanoma-specific model antigen led to more effective and sustained anti-tumor responses in mice.  ....

Massachusetts Institute Of Technology , United States , Tufts University , Spaulding Rehabilitation Hospital , University Of Massachusetts Medical School , Boston University , Benjamin Freedman , Katherine Williams , Maxence Dellacherie , Shannon Turley , Christina Tringides , Hamza Ijaz , Joel Gutierrez Estupinan , Giovanni Bovone , Alberto Elosegui Artola , Benjamin Boettner , Shawn Kang , Miguel Sobral , Robertp Pinkas , Alexander Najibi , Donald Ingber , David Mooney , Harvard Johna Paulson School Of Engineering , Farber Cancer Institute , Arts Sciences , National Institutes Of Health Cancer Institute ,

Lymph Node Expansion Enhances Vaccine Efficacy

Lymph Node Expansion Enhances Vaccine Efficacy
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United States , Katherine Williams , Shannon Turley , Maxence Dellacherie , Benjamin Freedman , Alberto Elosegui Artola , Benjamin Boettner , Joel Gutierrez Estupinan , Giovanni Bovone , Christina Tringides , Hamza Ijaz , Miguel Sobral , Shawn Kang , Robertp Pinkas , Alexander Najibi , Donald Ingber , David Mooney , Wyss Institute , Roche Group , Wyss Institute Founding Core Faculty , National Institutes Of Health Cancer Institute , Harvard Johna Paulson School Of Engineering , Biologically Inspired Engineering , Harvard University , Harvard John , Applied Sciences ,

Durable lymph-node expansion improves vaccine responses against tumors

Each one of us has around 600 lymph nodes (LNs) – small, bean-shaped organs that house various types of blood cells and filter lymph fluid – scattered throughout our bodies. ....

United States , Maxence Dellacherie , Hamza Ijaz , Joel Gutierrez Estupinan , Giovanni Bovone , Robertp Pinkas , David Mooney , Shannon Turley , Alberto Elosegui Artola , Donald Ingber , Christina Tringides , Miguel Sobral , Benjamin Freedman , Shawn Kang , Alexander Najibi , Katherine Williams , Harvard Johna Paulson School Of Engineering , Wyss Institute , National Institutes Of Health Cancer Institute , Roche Group , Wyss Institute Founding Core Faculty , Biologically Inspired Engineering , Harvard University , Harvard John , Applied Sciences , Nature Biomedical ,