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Alzheimers Patients Survival Bolstered by Donepezil, Memantine Combo

Alzheimer's disease is the world's most common neurodegenerative disease, affecting more than 50 million people globally. Alzheimer's disease is also ....

United States , Cyril Rakovski , Ehsan Yaghmaei , Chapman University , Data Sciences , Uc Irvine School Of Medicine , Chapel Hill School Of Medicine , Communications Medicine , Program Director , Orange County ,

'Cutting the cable' between CD8+ T and T regulatory cells enhances checkpoint immunotherapy

Checkpoint immunotherapy utilizing PD-1 blockade has become the standard of care for metastatic melanoma. While this treatment is effective in 40% of patients, the other 60% develop resistance, leading to tumor regrowth. A multidisciplinary research team led by the University of California, Irvine has identified a new strategy that could enhance the therapeutic effectiveness of this therapy by targeting the communication between immune cells within the tumor. ....

Irvine School , United States , Francesco Marangoni , Shannon Geels , Multiscale Cell Fate Research , Uc Irvine School Of Medicine , University Of California , Saint John Cancer Institute In Santa Monica , Department Of Physiology Biophysics , University Of Alabama At Birmingham , Institute For Immunology , Harvard Medical School , Cancer Cell , Complex Biological Systems , Simons Center , Saint John , Cancer Institute , Santa Monica , Massachusetts General Hospital , Harvard Medical , Treg Crosstalk Improves ,

Circadian clock can be leveraged to enhance cancer immunotherapy

A multidisciplinary research team has revealed that the circadian clock the biological pacemaker that governs daily rhythms in physiological processes, including immune functions can be leveraged to enhance the efficacy of checkpoint inhibitor cancer therapy. Checkpoint inhibitors block different proteins from binding to tumor cells, allowing the immune system s T cells to kill the tumor. ....

Selma Masri , V Foundation , Uc Irvine School Of Medicine , Department Of Biological Chemistry , National Cancer Institute , Nature Immunology , Bridget Fortin ,

Circadian Clock Boosts Cancer Immunotherapy, UCI Study Finds

Circadian Clock Boosts Cancer Immunotherapy, UCI Study Finds
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United States , Irvine School , Orange County , Howard Gillman , Selma Masri , Uc Irvine School Of Medicine , Department Of Biological Chemistry , University Of California , National Cancer Institute , V Foundation , Association Of American Universities , Nature Immunology , Bridget Fortin , American Universities , Chancellor Howard Gillman ,

Study reveals circadian clock can be leveraged to enhance cancer immunotherapy

Study reveals circadian clock can be leveraged to enhance cancer immunotherapy
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United States , Irvine School , Bridgetm Fortin , Selma Masri , Uc Irvine School Of Medicine , University Of California , Department Of Biological Chemistry , Nature Immunology , Bridget Fortin ,