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'Cutting the cable' between CD8+ T and T regulatory cells enhances checkpoint immunotherapy

Checkpoint immunotherapy utilizing PD-1 blockade has become the standard of care for metastatic melanoma. While this treatment is effective in 40% of patients, the other 60% develop resistance, leading to tumor regrowth. A multidisciplinary research team led by the University of California, Irvine has identified a new strategy that could enhance the therapeutic effectiveness of this therapy by targeting the communication between immune cells within the tumor. ....

Irvine School , United States , Francesco Marangoni , Shannon Geels , Multiscale Cell Fate Research , Uc Irvine School Of Medicine , University Of California , Saint John Cancer Institute In Santa Monica , Department Of Physiology Biophysics , University Of Alabama At Birmingham , Institute For Immunology , Harvard Medical School , Cancer Cell , Complex Biological Systems , Simons Center , Saint John , Cancer Institute , Santa Monica , Massachusetts General Hospital , Harvard Medical , Treg Crosstalk Improves ,

Scientists develop "x-ray vision" technique t

Scientists develop "x-ray vision" technique t
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Sanjib Paul , Adam Hauser , Stefano Sacanna , Shihao Zang , Glen Hocky , Simons Center , York University , National Institute Of Health , Us Army Research Office , New York University , Computational Physical Chemistry , Research Office , National Institute , Performance Computing ,