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'Cutting the cable' between CD8+ T and T regulatory cells enhances checkpoint immunotherapy

Checkpoint immunotherapy utilizing PD-1 blockade has become the standard of care for metastatic melanoma. While this treatment is effective in 40% of patients, the other 60% develop resistance, leading to tumor regrowth. A multidisciplinary research team led by the University of California, Irvine has identified a new strategy that could enhance the therapeutic effectiveness of this therapy by targeting the communication between immune cells within the tumor. ....

Irvine-school , California , United-states , Irvine , Massachusetts , Francesco-marangoni , Shannon-geels , Multiscale-cell-fate-research , Uc-irvine-school-of-medicine , University-of-california , Saint-john-cancer-institute-in-santa-monica , Department-of-physiology-biophysics

Cancer Surge: Scientists Baffled by Sudden Rise in Number of Cases Among Young Americans

Scientists are baffled by the rise in cancer diagnosis among younger Americans, particularly in women, in the last decade. ....

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