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'Cutting the cable' between CD8+ T and T regulatory cells enhances checkpoint immunotherapy

Checkpoint immunotherapy utilizing PD-1 blockade has become the standard of care for metastatic melanoma. While this treatment is effective in 40% of patients, the other 60% develop resistance, leading to tumor regrowth. A multidisciplinary research team led by the University of California, Irvine has identified a new strategy that could enhance the therapeutic effectiveness of this therapy by targeting the communication between immune cells within the tumor. ....

Irvine-school , California , United-states , Irvine , Massachusetts , Francesco-marangoni , Shannon-geels , Multiscale-cell-fate-research , Uc-irvine-school-of-medicine , University-of-california , Saint-john-cancer-institute-in-santa-monica , Department-of-physiology-biophysics

Checkpoint Therapy Could Be Enhanced by Cutting CD8+ T Cell/Treg Crosstalk

Checkpoint Therapy Could Be Enhanced by Cutting CD8+ T Cell/Treg Crosstalk
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California , United-states , Irvine , Francesco-marangoni , Shannon-geels , Department-of-physiology , University-of-california , Cancer-cell ,

Cancer immunotherapy may self-limit its efficacy in fighting tumors, study finds

Cancer immunotherapy may self-limit its efficacy in fighting tumors, study finds
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California , United-states , Irvine , Emily-henderson , Francesco-marangoni , University-of-california , Institute-for-immunology , கலிஃபோர்னியா , ஒன்றுபட்டது-மாநிலங்களில் , இவைந் , எமிலி-ஹென்டர்சன் , பல்கலைக்கழகம்-ஆஃப்-கலிஃபோர்னியா