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'Cutting the cable' between CD8+ T and T regulatory cells enhances checkpoint immunotherapy

Checkpoint immunotherapy utilizing PD-1 blockade has become the standard of care for metastatic melanoma. While this treatment is effective in 40% of patients, the other 60% develop resistance, leading to tumor regrowth. A multidisciplinary research team led by the University of California, Irvine has identified a new strategy that could enhance the therapeutic effectiveness of this therapy by targeting the communication between immune cells within the tumor. ....

Irvine School , United States , Francesco Marangoni , Shannon Geels , Multiscale Cell Fate Research , Uc Irvine School Of Medicine , University Of California , Saint John Cancer Institute In Santa Monica , Department Of Physiology Biophysics , University Of Alabama At Birmingham , Institute For Immunology , Harvard Medical School , Cancer Cell , Complex Biological Systems , Simons Center , Saint John , Cancer Institute , Santa Monica , Massachusetts General Hospital , Harvard Medical , Treg Crosstalk Improves ,

Covid silver lining: Unprecedented look at human immune system

The pandemic offered the first-ever opportunity for scientists to study how the immune system responds to a new threat, in real time, in the global population. ....

San Francisco , United States , Marion Koopmans , Paul Bieniasz , Steven Deeks , Marc Veldhoen , Ali Ellebedy , Scott Hensley , John Wherry , Rafi Ahmed , Kristian Andersen , Alessandro Sette , Stanley Perlman , Jolla Institute For Immunology , Penn Institute Of Immunology , Rockefeller University , Scripps Research , Institute For Immunology , Washington University In St , University Of California , Erasmus Medical Center , University Of Iowa Carver College Medicine , Emory University Vaccine Center , University Of Lisbon , University Of Washington School Medicine , University Of Pennsylvania ,

A step toward personalized immunotherapy for

<p>New research opens the door to developing vaccines or therapies to increase T cell numbers and treat many more types of cancer than currently thought possible.</p>
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San Diego , United States , La Jolla , Martins Naradikian , Samirs Makani , Rukmanr Thota , Milad Bahmanof , Ezra Cohen , Manasa Lanka , Karla Soria Zavala , Leslie Montero , Ashmitaa Logandha Ramamoorthy Premlal , Jason Greenbaum , Alessandro Sette , Luise Westernberg , Gregory Seumois , Stephen Schoenberger , Scottm Lippman , Zeynep Ko , Spencere Brightman , Aaronm Miller , Bjoern Peters , Angela Frentzen , Fernanda Whitworth , Uc San Diego Health , Uc San Diego Moores Cancer Center ,

How T cells combat tuberculosis

<p>Scientists at La Jolla Institute for Immunology (LJI) have uncovered important clues to how human T cells combat <em>Mycobacterium tuberculosis,</em> the bacterium that causes TB.</p>
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Sri Lanka , Bandu Gunasena , Judy Sb Perera , Arunad Desilva , Donaldg Catanzaro , Nelly Ciobanu , Jeffrey Morgan , Catherine Cheng , Cecilia Lindestam Arlehamn , Teshan Chathuranga , Lindestam Arlehamn , Bjoern Peters , Mayuko Saito , Valeriu Crudu , Timothy Rodwell , Roberth Gilman , Nature Communications , Research Assistant Professor , World Health Organization , Method Of Research , Jolla Institute , Jolla Institute For Immunology , National Institutes Of Health , Institute For Immunology , Assistant Professor , Health Organization ,

With Covid and flu surging at the same time, how big is the risk of coinfection?

This year’s respiratory virus season is already looking different than last year’s — with Covid and flu both surging. Here's what to know. ....

Stanford Scott , Jake Scott , John Wherry , Institute For Immunology , University Of Pennsylvania , International Journal Of Infectious Diseases , Drug Administration , Stanford Hospital , International Journal , Infectious Diseases , Flu Vaccines , Michael Phillips , Respiratory Virus , John Wherry ,