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Fundamental mechanism discovered that fine-tunes gene expression & is disrupted in cancer


Credit: The Wistar Institute
PHILADELPHIA and MELBOURNE, Australia (May. 17, 2021) A team of scientists from The Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, discovered a new checkpoint mechanism that fine-tunes gene transcription. As reported in a study published in
Cell, a component of the Integrator protein complex tethers the protein phosphatase 2A (PP2A) to the site of transcription allowing it to stop the activity of the RNA polymerase II enzyme (RNAPII). Disruption of this mechanism leads to unrestricted gene transcription and is implicated in cancer.
The study points to new viable opportunities for therapeutic intervention demonstrating the anti-cancer effect of a new combination treatment in preclinical models of solid and hematopoietic malignancies. ....

New York , United States , Dana Farber Cancer Institute , New South Wales , Benjamin Blyth , Otto Kauko , Jenniferr Devlin , Saraha Welsh , Elisa Barbieri , Kaylenej Simpson , Edwind Hawkins , Michael Ohlmeyer , Deboraha Knight , Matteo Costacurta , Stefan Bjelosevic , Gareth Gregory , Simonj Hogg , Ricky Johnstone , Elena Demosthenous , Magnus Zethoven , Jarrodj Sandow , Benp Martin , Conorj Kearney , Izabela Todorovski , Joseph Ha Vissers , Madisonj Kelly ,

Researchers discover novel non-coding RNAs regulating blood vessel formation


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Credit: UEF/ Raija Törrönen
Researchers at the University of Eastern Finland have discovered previously unknown non-coding RNAs (ncRNAs) involved in regulating the gene expression of vascular endothelial growth factors (VEGF), the master regulators of angiogenesis. The study, conducted by the research groups of Associate Professor Minna Kaikkonen-Määttä and Academy Professor Seppo Ylä-Herttuala, provides a better understanding of the complex interplay of ncRNAs with gene regulation, which might open up novel therapeutic approaches in the future. The results were published in the
Molecular and Cellular Biology Journal.
Over the past years, the development of next generation sequencing techniques has revealed that around 97% of the human transcriptome is transcribed as non-coding RNAs, and although the role of the vast majority remains uncharacterized, many functions such as gene regulation have been proven. ....

Landskapet Birkaland , Nihay Laham Karam , Minna Kaikkonen , Centre Of Excellence , Academy Research , Ai Virtanen Institute For Molecular Sciences , Finnish Cultural Foundation , Academy Professor Seppo Yl , University Of Eastern Finland , Finnish Foundation For Cardiovascular Research , Academy Of Finland , European Research Council , Eastern Finland , Associate Professor Minna Kaikkonen M , Cellular Biology , Metabolic Diseases , Sigrid Jus , Finnish Foundation , Cardiovascular Research , Finnish Cultural , Research Fellow , Molecular Sciences , Professor Nihay Laham Karam , மையம் ஆஃப் சிறப்பானது , கலைக்கழகம் ஆராய்ச்சி , பின்னிஷ் கலாச்சார அடித்தளம் ,

Promising results from first-in-humans study of a novel PET radiopharmaceutical


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IMAGE: The inflamed joints of a rheumatoid arthritis patient are clearly visible in the PET images with the novel 68Ga-DOTA-Siglec-9 radiopharmaceutical.
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Credit: Anne Roivainen
The preliminary trial results of a novel radiopharmaceutical for PET imaging of inflammation developed at the University of Turku, Finland, have been published. The compound, which targets the vascular adhesion protein 1 (VAP-1) that regulates inflammatory cell traffic, is the first radiopharmaceutical that has been developed completely in Finland and has advanced to clinical trials. In the study that started with healthy volunteers, the radiopharmaceutical was found to be well tolerated and safe.
The radiopharmaceutical is 68Ga-labelled Siglec-9 peptide. ....

Southwest Finland , Sirpa Jalkanen , Olli Moisio , Riikka Viitanen , Anne Roivainen , Akademi University , Finnish Foundation For Cardiovascular Research , University Of Turku , Academy Of Finland , Finnish Cultural Foundation , Turku University Hospital , Aatos Erkko Foundation , Researchers Riikka Viitanen , Professor Anne Roivainen , Hospital District , Sigrid Jus , Business Finland , Finnish Foundation , Nuclear Medicine , Medicine Health , Clinical Trials , தென்மேற்கு பின்லாந்து , பின்னிஷ் அடித்தளம் க்கு இருதய ஆராய்ச்சி , பல்கலைக்கழகம் ஆஃப் டர்கு , கலைக்கழகம் ஆஃப் பின்லாந்து , பின்னிஷ் கலாச்சார அடித்தளம் ,