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Credit: UEF/ Raija Törrönen
Researchers at the University of Eastern Finland have discovered previously unknown non-coding RNAs (ncRNAs) involved in regulating the gene expression of vascular endothelial growth factors (VEGF), the master regulators of angiogenesis. The study, conducted by the research groups of Associate Professor Minna Kaikkonen-Määttä and Academy Professor Seppo Ylä-Herttuala, provides a better understanding of the complex interplay of ncRNAs with gene regulation, which might open up novel therapeutic approaches in the future. The results were published in the
Molecular and Cellular Biology Journal.
Over the past years, the development of next generation sequencing techniques has revealed that around 97% of the human transcriptome is transcribed as non-coding RNAs, and although the role of the vast majority remains uncharacterized, many functions such as gene regulation have been proven. ....

Landskapet Birkaland , Nihay Laham Karam , Minna Kaikkonen , Centre Of Excellence , Academy Research , Ai Virtanen Institute For Molecular Sciences , Finnish Cultural Foundation , Academy Professor Seppo Yl , University Of Eastern Finland , Finnish Foundation For Cardiovascular Research , Academy Of Finland , European Research Council , Eastern Finland , Associate Professor Minna Kaikkonen M , Cellular Biology , Metabolic Diseases , Sigrid Jus , Finnish Foundation , Cardiovascular Research , Finnish Cultural , Research Fellow , Molecular Sciences , Professor Nihay Laham Karam , மையம் ஆஃப் சிறப்பானது , கலைக்கழகம் ஆராய்ச்சி , பின்னிஷ் கலாச்சார அடித்தளம் ,