34 Monash University research projects have been awarded a combined total of more than $62.9 million in the latest National Health and Medical Research Council (NHMRC) Investigator Grants scheme.NHMRC Investigator Grants provide the highest-performin
Residents in villages such as East Morton and Denholme and the suburb of Wibsey, in West Yorkshire, have condemnted the extra traffic, noise and fumes in their neighbourhoods.
Credit: The Wistar Institute
PHILADELPHIA and MELBOURNE, Australia (May. 17, 2021) A team of scientists from The Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, discovered a new checkpoint mechanism that fine-tunes gene transcription. As reported in a study published in
Cell, a component of the Integrator protein complex tethers the protein phosphatase 2A (PP2A) to the site of transcription allowing it to stop the activity of the RNA polymerase II enzyme (RNAPII). Disruption of this mechanism leads to unrestricted gene transcription and is implicated in cancer.
The study points to new viable opportunities for therapeutic intervention demonstrating the anti-cancer effect of a new combination treatment in preclinical models of solid and hematopoietic malignancies.