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More than $62.9 million awarded to Monash for vital medical research

34 Monash University research projects have been awarded a combined total of more than $62.9 million in the latest National Health and Medical Research Council (NHMRC) Investigator Grants scheme.NHMRC Investigator Grants provide the highest-performin ....

South Australia , Patrick Kwan , Shobi Sivathamboo , Benjamin Marsland , Ron Firestein , Jessica Biesiekierski , Omer Gilan , Patrick Sexton , Joseph Doyle , Mark Bellgrove , Adam Shahine , Marcus Chen , Suzanne Nielsen , Stacey Ellery , William Roman , Daniel Rolnik , Ian Harding , Jian Li , Ram Bhusal , Vilija Jokubaitis , Rebecca Goldstein , Karla Hutt , Jeremy Barr , Gareth Gregory , Denise Oconnor , Romain Ragonnet ,

Fundamental mechanism discovered that fine-tunes gene expression & is disrupted in cancer


Credit: The Wistar Institute
PHILADELPHIA and MELBOURNE, Australia (May. 17, 2021) A team of scientists from The Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, discovered a new checkpoint mechanism that fine-tunes gene transcription. As reported in a study published in
Cell, a component of the Integrator protein complex tethers the protein phosphatase 2A (PP2A) to the site of transcription allowing it to stop the activity of the RNA polymerase II enzyme (RNAPII). Disruption of this mechanism leads to unrestricted gene transcription and is implicated in cancer.
The study points to new viable opportunities for therapeutic intervention demonstrating the anti-cancer effect of a new combination treatment in preclinical models of solid and hematopoietic malignancies. ....

New York , United States , Dana Farber Cancer Institute , New South Wales , Benjamin Blyth , Otto Kauko , Jenniferr Devlin , Saraha Welsh , Elisa Barbieri , Kaylenej Simpson , Edwind Hawkins , Michael Ohlmeyer , Deboraha Knight , Matteo Costacurta , Stefan Bjelosevic , Gareth Gregory , Simonj Hogg , Ricky Johnstone , Elena Demosthenous , Magnus Zethoven , Jarrodj Sandow , Benp Martin , Conorj Kearney , Izabela Todorovski , Joseph Ha Vissers , Madisonj Kelly ,