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Latest single cell technology identifies cell types related to CAD pathogenesis

A new study from the University of Eastern Finland identified 12 different cell types involved in the pathogenesis of coronary artery disease, CAD. The researchers also showed that the genetic risk factors for CAD take their effect especially via smooth vascular muscle cells, which change their phenotype as the disease progresses. ....

United States , Minna Kaikkonen , Lily Ramsey , Ai Virtanen Institute For Molecular Sciences , University Of Eastern Finland , Eastern Finland , Professor Minna Kaikkonen M , Virtanen Institute , Molecular Sciences , Professor Kaikkonen M , American Journal , Coronary Artery Disease ,

Study unearths 12 different cell types involved in the pathogenesis of coronary artery disease

A new study from the University of Eastern Finland identified 12 different cell types involved in the pathogenesis of coronary artery disease, CAD. ....

United States , Minna Kaikkonen , Emily Henderson , University Of Eastern Finland , Ai Virtanen Institute For Molecular Sciences , Eastern Finland , Professor Minna Kaikkonen M , Virtanen Institute , Molecular Sciences , Professor Kaikkonen M , Minna Kaikkonen M , American Journal , Coronary Artery Disease ,

Cell-type-specific insight into the function of risk factors in coronary artery disease

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IMAGE: The researchers analysed the contribution of the five main cell types involved in coronary artery disease.
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Credit: UEF/Raija Törrönen
Using single cell technology, a new study sheds light on the significance of genetic risk factors for, and the diversity of cells involved in, the development of coronary artery disease. The researchers analysed human atherosclerotic lesions to map the chromatin accessibility of more than 7,000 cells. The chromatin accessibility is known to reflect active regions and genes in the genome. The findings were published in
Circulation Research.
Genome-wide association studies of the human genome have identified over 200 loci associated with coronary artery disease. More than 90% of them are located outside protein-coding genes, in so called cis-regulatory elements, whose significance in the pathogenesis of coronary artery disease remains unclear. ....

United States , Landskapet Birkaland , Seppo Yl , Minna Kaikkonen , European Union Horizon , Herttuala University Of Eastern Finland , American Heart Association , Academy Research , Ai Virtanen Institute For Molecular Sciences , Casey Romanoski University Of Arizona , University Of Eastern Finland , University Of Turku , Academy Of Finland , European Research Council , Us National Institutes Of Health , Mete Civelek University Of Virginia , Circulation Research , Cardiovascular Genomics , Associate Professor Minna Kaikkonen M , Eastern Finland , Mete Civelek , Casey Romanoski , European Union , Sigrid Jus , Research Fellow , Molecular Sciences ,

Study uncovers mechanisms by which microRNAs drive atherogenesis in a cell-type-specific manner

Researchers at the University of Eastern Finland have uncovered potential mechanisms by which microRNAs (miRNA) drive atherogenesis in a cell-type-specific manner. ....

Minna Kaikkonen , Emily Henderson , Emil Aaltonen Foundation , Maud Kuistila Memorial Foundation , University Of Eastern Finland , Aatos Erkko Foundation , Orion Research Foundation , Finnish Foundation For Cardiovascular Research , Academy Of Finland , Georg Ehrnrooth Foundation , European Research Council , Eastern Finland , Vascular Biology , Associate Professor Minna Kaikkonen M , Finnish Foundation , Cardiovascular Research , Sigrid Jus , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் கிழக்கு பின்லாந்து , ஒரையந் ஆராய்ச்சி அடித்தளம் , பின்னிஷ் அடித்தளம் க்கு இருதய ஆராய்ச்சி , கலைக்கழகம் ஆஃப் பின்லாந்து , ஐரோப்பிய ஆராய்ச்சி சபை , கிழக்கு பின்லாந்து , வாஸ்குலர் உயிரியல் , பின்னிஷ் அடித்தளம் ,

MicroRNAs may contribute to atherogenesis in a cell-type-dependent manner

Researchers at the University of Eastern Finland have uncovered potential mechanisms by which microRNAs (miRNA) drive atherogenesis in a cell-type-specific manner. Published in the Arteriosclerosis, Thrombosis, and Vascular Biology journal, the study provides novel insight into the miRNA profiles of the main cell types involved in atherosclerosis. ....

United Kingdom , Landskapet Birkaland , Minnau Kaikkonen , Seppo Yl , Maria Bouvy Liivrand , Heidih Pulkkinen , Suvi Linna Kuosmanen , Merja Hein , Minna Kaikkonen , Vanesa Tomas Bosch , Pierrer Moreau , Johannap Laakkonen , Broad Institute , Artificial Intelligence Laboratory , Academy Research , Ai Virtanen Institute For Molecular Sciences , Emil Aaltonen Foundation , University Of Eastern Finland , Maud Kuistila Memorial Foundation , Aatos Erkko Foundation , Orion Research Foundation , Finnish Foundation For Cardiovascular Research , Academy Of Finland , European Research Council , Georg Ehrnrooth Foundation , Eastern Finland ,