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Using next-gen CRISPR tool, Gladstone scienti

<p>In a study of historic scale, scientists at Gladstone Institutes have created an intricate map of how the immune system functions, examining the detailed molecular structures governing human T cells using the next-generation CRISPR tool known as base editing. Their findings, published in <em>Nature</em>, uncover detailed information that could help overcome the limitations of today’s immunotherapies and identify new drug targets for a wide range of diseases, including autoimmune diseases and cancer. </p>
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San Francisco , United States , Mission Bay , Justin Eyquem , Carl Ward , Vincent Allain , Galen Xing , Rama Dajani , Lukea Gilbert , Jonathank Pritchard , Rosmely Hernandez , Staciee Dodgson , Ralf Schmidt , Mineto Ota , Alex Marson , Charlotte Wang , Yan Yi Chen , Laine Goudy , University Of Vienna , Institute Of Genomic Immunology , Gladstone Institutes , Gladstone Senior Investigator Alex Marson , Genomic Immunology , Parker Institute , Medical University , Zev Armour Garb ,

Lego-Like Gene Editing Tool Lets Researchers Improve Cancer Immunotherapy

Scientists used a new method to screen 10,000 combinations of gene edits in immune cells engineered to fight cancer ....

San Francisco , United States , Stanford School , Mission Bay , Eric Shifrut , Torin Yamamoto , Barbara Bakar , Raymund Bueno , Yan Yi Chen , Elena Radutzky , Peixin Amy Chen , Julie Langelier , Cheol Kim , Justin Eyquem , Tobias Feuchtinger , Franziska Blaeschke , Chan Zuckerberg Biohub , Williama Nyberg , Cody Mowery , Ansuman Satpathy , Ralf Schmidt , Theodore Roth , Wenxi Zhang , Andyy Chen , Ruby Yu , Bence Daniel ,

Lego-Like Gene Editing Tool Lets Researchers Improve Cancer Immunotherapy

/PRNewswire/ In recent years, scientists have used gene modification technologies to reprogram immune cells into therapeutics that can attack cancers. But. ....

Stanford School , United States , Mission Bay , San Francisco , Alex Marson , Bence Daniel , Elena Radutzky , Ansuman Satpathy , Yan Yi Chen , Andyy Chen , Theodore Roth , Ralf Schmidt , Julia Carnevale , Zhongmei Li , Cody Mowery , Williama Nyberg , Tobias Feuchtinger , Chan Zuckerberg Biohub , Torin Yamamoto , Peixin Amy Chen , Franziska Blaeschke , Justin Eyquem , Cheol Kim , Danielb Goodman , Wenxi Zhang , Barbara Bakar ,

Giving Immunotherapy Cells Resilience to Pass the 'Stress Test'

T cells used in immunotherapy treatments can get exhausted and shut down by fighting cancer cells and tumors. Using a CRISPR-based edit on these cells’ genomes, researchers at UCSF and Gladstone Institutes have rendered the therapeutic cells more resilient against tumors. ....

United States , San Francisco , Nupura Kale , Bence Daniel , Shane Vedova , Julia Belk , Shannon Lange , Yan Yi Chen , Marie Luetke Eversloh , Williama Nyberg , Theodorel Roth , Zhongmei Li , Eric Shifrut , Scott Kogan , Brooke Prinzing , Dalia Haydar , Giedre Krenciute , Alex Marson , Justin Eyquem , Sagarp Bapat , Kevin Shannon , Alan Ashworth Julia Carnevale , Jorge Iba , Stefanie Bachl , Alex Ritter , Julia Carnevale ,

Giving Immunotherapy Cells Resilience to Pass "Stress Test"

Giving Immunotherapy Cells Resilience to Pass "Stress Test"
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United States , San Francisco , Nupura Kale , Bence Daniel , Shane Vedova , Julia Belk , Shannon Lange , Yan Yi Chen , Marie Luetke Eversloh , Williama Nyberg , Theodorel Roth , Zhongmei Li , Eric Shifrut , Scott Kogan , Brooke Prinzing , Dalia Haydar , Giedre Krenciute , Alex Marson , Justin Eyquem , Sagarp Bapat , Kevin Shannon , Jorge Iba , Stefanie Bachl , Alex Ritter , Julia Carnevale , Tobias Feuchtinger ,