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CRISPR-based mapping uncovers 'switches' for immune genes central to health

Healthy T cells are the foundation of a balanced immune system. They can spring into action to fight off infections or cancer, but keep from becoming so activated that they hurt the very cells they re meant to protect, as is the case in autoimmune diseases.

Using next-gen CRISPR tool, scientists create unprecedented molecular map of human immune response

Using next-gen CRISPR tool, Gladstone scienti

<p>In a study of historic scale, scientists at Gladstone Institutes have created an intricate map of how the immune system functions, examining the detailed molecular structures governing human T cells using the next-generation CRISPR tool known as base editing.&nbsp;Their findings, published in <em>Nature</em>, uncover detailed information that could help overcome the limitations of today&rsquo;s immunotherapies and identify new drug targets for a wide range of diseases, including autoimmune diseases and cancer.&nbsp;</p>

Using next-gen CRISPR tool, scientists create unprecedented molecular map of human immune response