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Giving Immunotherapy Cells Resilience to Pass the 'Stress Test'

T cells used in immunotherapy treatments can get exhausted and shut down by fighting cancer cells and tumors. Using a CRISPR-based edit on these cells’ genomes, researchers at UCSF and Gladstone Institutes have rendered the therapeutic cells more resilient against tumors. ....

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A Cellular Engineering Breakthrough: High-Yield CRISPR Without Viral Vectors

/PRNewswire/ A new variation of the CRISPR-Cas9 gene editing system makes it easier to re-engineer massive quantities of cells for therapeutic applications.. ....

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A Cellular Engineering Breakthrough: High-Yield CRISPR Without Viral Vectors

A Cellular Engineering Breakthrough: High-Yield CRISPR Without Viral Vectors
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Giving Immunotherapy Cells Resilience to Pass "Stress Test"

Giving Immunotherapy Cells Resilience to Pass "Stress Test"
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Gene Editing Expands to New Types of Immune Cells

Gene Editing Expands to New Types of Immune Cells
Gladstone researchers fine-tuned CRISPR-Cas9 genome editing to work on human immune cells called monocytes
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SAN FRANCISCO, May 11, 2021 /PRNewswire/ In the decade since the advent of CRISPR-Cas9 gene editing, researchers have used the technology to delete or change genes in a growing number of cell types. Now, researchers at Gladstone Institutes and UC San Francisco (UCSF) have added human monocytes white blood cells that play key roles in the immune system to that list.
A team of scientists at Gladstone Institutes and UC San Francisco led by Alex Marson (left) and Nevan Krogan (right) fine-tuned CRISPR-Cas9 genome editing to help understand how the human immune system fights viruses and microbes. ....

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