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Lego-Like Gene Editing Tool Lets Researchers Improve Cancer Immunotherapy

Scientists used a new method to screen 10,000 combinations of gene edits in immune cells engineered to fight cancer ....

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Lego-Like Gene Editing Tool Lets Researchers Improve Cancer Immunotherapy

/PRNewswire/ In recent years, scientists have used gene modification technologies to reprogram immune cells into therapeutics that can attack cancers. But. ....

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Giving Immunotherapy Cells Resilience to Pass the 'Stress Test'

T cells used in immunotherapy treatments can get exhausted and shut down by fighting cancer cells and tumors. Using a CRISPR-based edit on these cells’ genomes, researchers at UCSF and Gladstone Institutes have rendered the therapeutic cells more resilient against tumors. ....

United States , San Francisco , Nupura Kale , Bence Daniel , Shane Vedova , Julia Belk , Shannon Lange , Yan Yi Chen , Marie Luetke Eversloh , Williama Nyberg , Theodorel Roth , Zhongmei Li , Eric Shifrut , Scott Kogan , Brooke Prinzing , Dalia Haydar , Giedre Krenciute , Alex Marson , Justin Eyquem , Sagarp Bapat , Kevin Shannon , Alan Ashworth Julia Carnevale , Jorge Iba , Stefanie Bachl , Alex Ritter , Julia Carnevale ,

Using the power of CRISPR to engineer better, stronger, longer-lived T cells

T cells used in immunotherapy treatments can get exhausted by the task of fighting cancer cells or get shutdown as they enter tumors. ....

Justin Eyquem , Eric Shifrut , Giedre Krenciute , Julia Carnevale , Alan Ashworth , Emily Henderson , Alex Marson , Jude Children Research Hospital , Institute Of Genomic Immunology , Department Of Medicine , Tel Aviv University , Helen Diller Family Comprehensive Cancer Center , Gladstone Institutes , Genomic Immunology , Helen Diller Family Comprehensive Cancer , Tel Aviv , Jude Children , Research Hospital , T Cell ,

A Cellular Engineering Breakthrough: High-Yield CRISPR Without Viral Vectors

/PRNewswire/ A new variation of the CRISPR-Cas9 gene editing system makes it easier to re-engineer massive quantities of cells for therapeutic applications.. ....

United States , San Francisco , Davidn Nguyen , Chan Zuckerberg Biohub , Shane Vedova , David Wu , Yan Yi Chien , Zhong Li , Carlose Castro , Theodorel Roth , Alexis Talbot , Jing Yi Chung , Eric Shifrut , Jeffrey Wolf , Muradr Mamedov , Jonathan Esensten , Weill Neurohub , Vivasvans Vykunta , Thomasg Martin , Alex Marson , Franziska Blaeschke , Ruby Yu , Wolfgangg Pfeifer , Justin Eyquem , Jennifer Doudna , University Of California ,