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Lung Chip Mimics Radiation Injury |

Lung Chip Mimics Radiation Injury |
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Human Lung Chip Leveraged to Faithfully Model Radiation-induced Lung Injury

Human life-like in vitro model of radiation damage sustained to the lung opens an unprecedented window into the early disease process, and opportunities for drug development ....

United States , Queeny Dasgupta , Donald Ingber , Drug Administration , Network Model For Causality , Wyss Institute , Harvard Johna Paulson School Of Engineering , Harvard Medical School , Nature Communications , Biologically Inspired Engineering , Harvard University , Boston Children , Wyss Founding Director , Lung Alveolus Chip , Lung Chip , Organ Chip , Folkman Professor , Vascular Biology , Wyss Professor , Bioinspired Engineering , Harvard John , Lung Alveolus , Postdoctoral Fellow , Systemic Bio , Organ Chips ,

Human Lung Chip leveraged to faithfully model radiation-induced lung injury

Human Lung Chip leveraged to faithfully model radiation-induced lung injury
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Lung chip model offers new insights into how radiation damages the lungs

The lung is one of the tissues most sensitive to radiation in the human body. People exposed to high radiation doses following nuclear incidents develop radiation-induced lung injury (RILI), which affects the function of many cell types in the lung, causing acute and sustained inflammation, and in the longer term, the thickening and scarring of lung tissue known as fibrosis. ....

United States , Emilia Javorsky , Lily Ramsey , Robert Mannix , Sean Hall , Amanda Jiang , Donald Ingber , Queeny Dasgupta , Amy Wen , Harvard Johna Paulson School Of Engineering , Nature Communications , Network Model For Causality , Wyss Institute , Drug Administration , Wyss Institute At Harvard University , Biologically Inspired Engineering , Harvard University , Boston Children , Wyss Founding Director Donald Ingber , Lung Alveolus Chip , Lung Chip , Organ Chip , Wyss Founding , Judah Folkman Professor , Vascular Biology , Harvard Medical School ,

Human Lung Chip leveraged to faithfully model

<p>Researchers have developed a human <em>in vitro</em> model that closely mimics the complexities of radiation-induced lung injury (RILI) and radiation dose sensitivity of the human lung. Using a previously developed microfluidic human Lung Alveolus Chip lined by human lung alveolar epithelial cells interfaced with lung capillary cells to recreate the alveolar-capillary interface <em>in vitro</em>, the researchers recapitulated many of the hallmarks of RILI, including radiation-induced DNA damage in lung tissue, cell-specific changes in gene expression, inflammation, and injury to both the lung epithelial cells and blood vessel-lining endothelial cells. By also evaluating the potential of two drugs to suppress the effects of acute RILI, the researchers demonstrated their model’s capabilities as an advanced, human-relevant, preclinical, drug discovery platform.</p>
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