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Cardiac antigen identified as mechanism for heart complication with immunotherapy-related myocarditis

Cardiac antigen identified as mechanism for heart complication with immunotherapy-related myocarditis
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Researchers discover the mechanism for heart complications from immune checkpoint inhibitors

Myocarditis is a complication that can occur in cancer patients treated with immune checkpoint inhibitors. ....

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San Diego Community News Group - Current vaccines teach T cells to fight Omicron

Current vaccines teach T cells to fight Omicron - Scientists at La Jolla Institute for Immunology (LJI) have found that four COVID-19 vaccines (Pfizer-BioNTech Moderna J&J/Janssen and Novavax) prompt the body to make effective long-lasting T cells. ....

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Genetic factors increase risk for severe COVID-19 illness: study

Genetic factors increase risk for severe COVID-19 illness: study
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T cells can mount attacks against many SARS-CoV-2 targets--even on new virus variant

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IMAGE: Transmission electron micrograph of SARS-CoV-2 virus particles, isolated from a patient. Image captured and color-enhanced at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland.
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Credit: NIAID
LA JOLLA A new study led by scientists at La Jolla Institute for Immunology (LJI) suggests that T cells try to fight SARS-CoV-2 by targeting a broad range of sites on the virus beyond the key sites on the virus s spike protein. By attacking the virus from many angles, the body has the tools to potentially recognize different SARS-CoV-2 variants.
The new research, published January 27, 2021 in
Cell Report Medicine, is the most detailed analysis so far of which proteins on SARS-CoV-2 stimulate the strongest responses from the immune system s helper CD4+ T cells and killer CD8+ T cells. ....

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