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Moderna and Pfizer-BioNTech vaccines prime T cells to fight SARS-CoV-2 variants

Moderna and Pfizer-BioNTech vaccines prime T cells to fight SARS-CoV-2 variants
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Moderna and Pfizer-BioNTech vaccines prime T cells to fight SARS-CoV-2 variants

Moderna and Pfizer-BioNTech vaccines prime T cells to fight SARS-CoV-2 variants
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AI predicts how patients with viral infections, including COVID-19, will fare

UC San Diego School of Medicine researchers discovered gene expression patterns associated with pandemic viral infections, providing a map to help define patients immune responses, measure disease severity, predict outcomes and test therapies for current and future pandemics.

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T cells can mount attacks against many SARS-CoV-2 targets--even on new virus variant

E-Mail IMAGE: Transmission electron micrograph of SARS-CoV-2 virus particles, isolated from a patient. Image captured and color-enhanced at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. view more Credit: NIAID LA JOLLA A new study led by scientists at La Jolla Institute for Immunology (LJI) suggests that T cells try to fight SARS-CoV-2 by targeting a broad range of sites on the virus beyond the key sites on the virus s spike protein. By attacking the virus from many angles, the body has the tools to potentially recognize different SARS-CoV-2 variants. The new research, published January 27, 2021 in Cell Report Medicine, is the most detailed analysis so far of which proteins on SARS-CoV-2 stimulate the strongest responses from the immune system s helper CD4+ T cells and killer CD8+ T cells.

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Protective immunity against SARS-CoV-2 could last eight months or more

Credit: Jenna Hambrick, La Jolla Institute for Immunology LA JOLLA New data suggest that nearly all COVID-19 survivors have the immune cells necessary to fight re-infection. The findings, based on analyses of blood samples from 188 COVID-19 patients, suggest that responses to the novel coronavirus, SARS-CoV-2, from all major players in the adaptive immune system, which learns to fight specific pathogens, can last for at least eight months after the onset of symptoms from the initial infection. Our data suggest that the immune response is there and it stays, LJI Professor Alessandro Sette, Dr. Biol. Sci., who co-led the study with LJI Professor Shane Crotty, Ph.D., and LJI Research Assistant Professor Daniela Weiskopf, Ph.D.

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