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Cardiac antigen identified as mechanism for heart complication with immunotherapy-related myocarditis

Cardiac antigen identified as mechanism for heart complication with immunotherapy-related myocarditis
dicardiology.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from dicardiology.com Daily Mail and Mail on Sunday newspapers.

United States , Margaret Axelrod , Jamesp Allison , Douglas Johnson , Justin Balko , Javid Moslehi , Vanderbilt Ingram Cancer Center , Vanderbilt Medical Scientist Training Program , Md Anderson Cancer Center , Balko Lab , Ingram Associate Professor Of Cancer Research , New England Journal , Ingram Associate Professor , Cancer Research , Cancer Center , Cancer Discovery ,

Cardiac Antigen Identified as Mechanism for Heart Complication

(HEALTH NEWS) Myocarditis is a complication that can occur in cancer patients treated with immune checkpoint inhibitors. Although the adverse event is rare — affecting less than 1% of patients given the immunotherapy — the mortality rate is nearly 50%.
Now, researchers from Vanderbilt-Ingram Cancer Center have identified the mechanism for the deadly heart inflammation.
The researchers discovered that T-cells recognizing the cardiac antigen α-myosin are the mechanism for this . ....

United States , Wouter Meijers , Yueli Zhang , Ayaka Sugiura , Javid Moslehi , Xiaopeng Sun , Warren Tai , Susan Opalenik , Juan Qin , Jeffrey Rathmell , Jamesc Bradford Jr , Abigail Toren , Margaret Axelrod , Jamesp Allison , Brandie Taylor , Elie Tannous , Douglas Johnson , Elizabeth Phillips , Ann Hanna , Kaushik Amancherla , Simon Mallal , P Brent Ferrell , Vanderbilt Ingram Cancer Center , Fund In Melanoma Cancer Research , National Institutes Of Health , Md Anderson Cancer Center ,

Cardiac antigen identified as mechanism for heart complication with immunotherapy-related myocarditis

Cardiac antigen identified as mechanism for heart complication with immunotherapy-related myocarditis
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

United States , Yueli Zhang , Ayaka Sugiura , Javid Moslehi , Xiaopeng Sun , Warren Tai , Susan Opalenik , Juan Qin , Jeffrey Rathmell , Jamesc Bradford Jr , Justin Balko , Abigail Toren , Margaret Axelrod , Jamesp Allison , Brandie Taylor , Elie Tannous , Douglas Johnson , Elizabeth Phillips , Ann Hanna , Kaushik Amancherla , Simon Mallal , P Brent Ferrell , Vanderbilt Ingram Cancer Center , Fund In Melanoma Cancer Research , National Institutes Of Health , Md Anderson Cancer Center ,

Researchers discover the mechanism for heart complications from immune checkpoint inhibitors

Myocarditis is a complication that can occur in cancer patients treated with immune checkpoint inhibitors. ....

United States , Yueli Zhang , Ayaka Sugiura , Emily Henderson , Javid Moslehi , Xiaopeng Sun , Warren Tai , Susan Opalenik , Juan Qin , Jeffrey Rathmell , Jamesc Bradford Jr , Justin Balko , Abigail Toren , Margaret Axelrod , Jamesp Allison , Brandie Taylor , Elie Tannous , Douglas Johnson , Elizabeth Phillips , Ann Hanna , Kaushik Amancherla , Simon Mallal , P Brent Ferrell , Vanderbilt Ingram Cancer Center , Fund In Melanoma Cancer Research , National Institutes Of Health ,

Arthritis drug may treat immunotherapy-related heart complication

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A drug typically prescribed for rheumatoid arthritis may also be effective in treating a rare but potentially deadly heart complication some cancer patients experience after taking immunotherapies, according to a study published in
Cancer Discovery and co-led by investigators at Vanderbilt University Medical Center (VUMC).
The researchers demonstrated that the drug abatacept reduced the severity of myocarditis in a genetic mouse model study - responses that have also been observed in three human patients who were given the same drug after corticosteroid treatments failed to reduce heart muscle inflammation. The mouse model revealed the mechanisms for how the drug works. ....

France General , United States , Wouter Meijers , Margaret Axelrod , Elizabeth Brunner Wescott , James Allison , Spencer Wei , Matthew Wlenkinski , Javid Moslehi , Lauren Himmel , Joe Elie Salem , Doug Johnson , Bjorn Knollmann , Justin Balko , Vanderbilt University Medical Center , National Cancer Institute , Sorbonne University , Oncology At Vanderbilt Ingram Cancer Center , National Institutes Of Health , Md Anderson Cancer Center , Cancer Discovery , Vanderbilt Ingram Cancer Center , Cancer Center , New England Journal , Elles Screever , Cancer Prevention ,