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Previously approved drugs starting points for COVID-19 therapeutics


Previously approved drugs starting points for COVID-19 therapeutics
Researchers in the United States have identified several clinically approved compounds that could be repurposed for the treatment and prevention of coronavirus disease 2019 (COVID-19).
By screening a commercial library of drugs that have already been approved by international regulatory agencies, the team identified more than 50 compounds that demonstrated some efficacy in blocking the initial stage of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the causative agent of COVID-19.
The compounds were able to disrupt the binding of a surface viral protein called Spike to its host cell receptor angiotensin-converting enzyme 2 (ACE2). ....

United States , Stephen Smith , Sally Robertson , Seattle Children Research Institute , Louis University School Of Medicine , Seattle Children , Research Institute , Louis University School , Angiotensin Converting Enzyme 2 , Binding Affinity , Corona Virus , Coronavirus Disease Covid 19 , Drug Discovery , In Vitro , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , மிச Ou ரி , ஸ்டீபன் ஸ்மித் , சாலி ராபர்ட்சன் , சீட்டில் குழந்தைகள் ஆராய்ச்சி நிறுவனம் , லூயிஸ் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , சீட்டில் குழந்தைகள் , ஆராய்ச்சி நிறுவனம் ,

Small molecule inhibitors of SARS-CoV-2 identified by screening


Small molecule inhibitors of SARS-CoV-2 identified by screening
Even as the vaccine rollout continues against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), seeking to bring an end to the coronavirus disease 2019 (COVID-19) pandemic, new variants emerge that show immune escape capabilities. Effective and safe drugs thus remain essential to treat severe infections with this virus.
A new preprint, released on the
bioRxiv server, describes the identification of small molecule inhibitors that block the catalytic activity of the crucial viral non-structural protein 5 (nsp5), using a large-scale screening method.
The importance of nsp5
At least nine enzymes of the virus are important for viral proliferation and are thus ideal for the development of antiviral drugs. These enzymes have the same sequence between different coronaviruses, unlike the spike, nucleocapsid and other structural proteins that are less conserved. This makes vaccines based on ....

Liji Thomas , Small Molecule Inhibitors , Image Credit , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , In Vitro , In Vivo , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Structural Protein , படம் கடன் , கொரோனா வைரஸ் , இல் விட்ரோ , இல் விவோ , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , கட்டமைப்பு ப்ரோடீந் ,

Researchers provide ultrastructural details of SARS-CoV-2-infected respiratory epithelial cells


Researchers provide ultrastructural details of SARS-CoV-2-infected respiratory epithelial cells
A team of scientists from the United Kingdom recently investigated the ultrastructural details of the attachment, entry, and budding processes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the human airway epithelium. They have used a highly differentiated air-liquid interface cultures of airway epithelium to thoroughly investigate the viral infection cycle. The study is currently available on the
Background
SARS-CoV-2, the causative pathogen of coronavirus disease 2019 (COVID-19), is an enveloped RNA virus belonging to the Coronaviridae family. The virus primarily attacks human airway epithelial cells to initiate infection. Mechanistically, the receptor-binding domain (RBD) of the S1 subunit of the viral spike glycoprotein binds to angiotensin-converting enzyme 2 (ACE2), which is ubiquitously expressed at the apical surface of host airway epithelial ce ....

United Kingdom , Juan Gaertner Shutterstock , Sanchari Sinha Dutta , Juan Gaertner , Coronavirus Disease Covid 19 , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Cell Membrane , Corona Virus , Electron Microscopy , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது கிஂக்டம் , சஞ்சரி சீன்ஹா தத்தா , ஜுவான் கேர்ட்னெற் , செல் சவ்வு , கொரோனா வைரஸ் , எதிர் மின்னணு , எதிர் மின்னணு நுண்ணோக்கி , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

CAL20.C SARS-CoV-2 variant skyrocketing in California evades host immune response


CAL20.C SARS-CoV-2 variant skyrocketing in California evades host immune response
The effect of different neutralizing antibodies, both vaccine-elicited and from convalescent sera, suggests new variants are emerging that can evade the human immune response.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to host cells via its spike protein, which has two parts, the S1 and S2 subunits. The S1 subunit has the receptor-binding domain (RBD) and the N-terminal domain (NTD). The RBD binds to the host angiotensin-converting enzyme 2 (ACE2) to infect host cells.
Neutralizing antibodies are produced against both the RBD and NTD by infected and vaccinated individuals. Some RBD-specific monoclonal antibodies are currently under clinical trials or approved for use to treat COVID-19 patients. ....

United States , Lakshmi Supriya , United States Centers For Disease Control , Phd Apr , United States Centers , Disease Control , Immune Response , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , லட்சுமி சுப்ரியா , ஒன்றுபட்டது மாநிலங்களில் மையங்கள் க்கு நோய் கட்டுப்பாடு , ஃப்ட் ஏப்ரல் , ஒன்றுபட்டது மாநிலங்களில் மையங்கள் , நோய் கட்டுப்பாடு , நோய் எதிர்ப்பு சக்தி பதில் , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants


The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants
A research group from the U.S. demonstrated the practicality of a spike display system in order to accelerate vaccine design, but also to swiftly appraise the effects of mutations in emerging strains of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Their results are currently available on the
bioRxiv preprint server.
SARS-CoV-2, the causative agent of the ongoing coronavirus disease (COVID-19), uses its spike glycoprotein to interact with angiotensin-converting enzyme 2 (ACE2) in order to fuse cell membrane and viral envelope. The key determinant of host tropism is the S1 subunit of the spike glycoprotein, composed of the receptor-binding domain (RBD) and N-terminal domain (NTD). ....

United States , South Africa , United Kingdom , South African , Kamyab Javanmardi , University Of Texas At Austin , Golden Gate , Coronavirus Disease Covid 19 , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Binding Affinity , Cell Membrane , Corona Virus , Immune Response , Polyclonal Antibody , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் இல் ஆஸ்டின் , தங்கம் வாயில் , பிணைப்பு இன உறவு , செல் சவ்வு , கொரோனா வைரஸ் , நோய் எதிர்ப்பு சக்தி பதில் , கடுமையானது எடுப்போசை சுவாச ,