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Researchers provide ultrastructural details of SARS-CoV-2-infected respiratory epithelial cells


Researchers provide ultrastructural details of SARS-CoV-2-infected respiratory epithelial cells
A team of scientists from the United Kingdom recently investigated the ultrastructural details of the attachment, entry, and budding processes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the human airway epithelium. They have used a highly differentiated air-liquid interface cultures of airway epithelium to thoroughly investigate the viral infection cycle. The study is currently available on the
Background
SARS-CoV-2, the causative pathogen of coronavirus disease 2019 (COVID-19), is an enveloped RNA virus belonging to the Coronaviridae family. The virus primarily attacks human airway epithelial cells to initiate infection. Mechanistically, the receptor-binding domain (RBD) of the S1 subunit of the viral spike glycoprotein binds to angiotensin-converting enzyme 2 (ACE2), which is ubiquitously expressed at the apical surface of host airway epithelial ce ....

United Kingdom , Juan Gaertner Shutterstock , Sanchari Sinha Dutta , Juan Gaertner , Coronavirus Disease Covid 19 , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Cell Membrane , Corona Virus , Electron Microscopy , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது கிஂக்டம் , சஞ்சரி சீன்ஹா தத்தா , ஜுவான் கேர்ட்னெற் , செல் சவ்வு , கொரோனா வைரஸ் , எதிர் மின்னணு , எதிர் மின்னணு நுண்ணோக்கி , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,

Tiny SARS-CoV-2 protein may have big implications for future COVID-19 treatments


Tiny SARS-CoV-2 protein may have big implications for future COVID-19 treatments
A tiny protein of SARS-CoV-2, the coronavirus that gives rise to COVID-19, may have big implications for future treatments, according to a team of Penn State researchers.
Using a novel toolkit of approaches, the scientists uncovered the first full structure of the Nucleocapsid (N) protein and discovered how antibodies from COVID-19 patients interact with that protein. They also determined that the structure appears similar across many coronaviruses, including recent COVID-19 variants making it an ideal target for advanced treatments and vaccines. They reported their results in
Nanoscale.
We discovered new features about the N protein structure that could have large implications in antibody testing and the long-term effects of all SARS-related pandemic viruses. Since it appears that the N protein is conserved across the variants of SARS-CoV-2 and SARS-CoV-1, therapeutics designed to ....

South Africa , United States , United Kingdom , Deb Kelly , Michael Casasanta , Emily Henderson , Penn State Center , Protochips Inc , Penn State , Huck Chair , Molecular Biophysics , Raybiotech Life , Direct Electron , Corona Virus , Sars Cov 2 , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , டெப் கெல்லி , எமிலி ஹென்டர்சன் , பென் நிலை மையம் , பென் நிலை , ஹக் நாற்காலி , மூலக்கூறு உயிர் இயற்பியல் , நேரடி எதிர் மின்னணு , கொரோனா வைரஸ் ,