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Local anesthetic procaine inhibits SARS-CoV-2 in vitro

Research has shown that procaine and procaine-hydrochloride can reduce replication of SARS-CoV-2 and influenza A viruses in infected cells and reduce the production of cytokines by the viruses, making them potentially useful for treating COVID-19. ....

Lakshmi Supriya , Phd Jun , Image Credit , In Vitro , Ars Cov 2 , Ell Death , Coronavirus Disease Covid 19 , Immune System , Pulmonary Edema , Evere Acute Respiratory , Evere Acute Respiratory Syndrome , Spike Protein , லட்சுமி சுப்ரியா , ஃப்ட் ஜூன் , படம் கடன் , இல் விட்ரோ ,

Plant-based oil blend shows virucidal activity against SARS-CoV-2 and influenza viruses in vitro

A new preprint research paper posted to the bioRxiv server offers a potential candidate for disinfecting the respiratory tract and mouth during and after exposure to the virus, in the form of proprietary herbal oil named Viruxal. ....

Liji Thomas , Image Credit , In Vitro , Ars Cov 2 , Coronavirus Disease Covid 19 , Fatty Acids , Linoleic Acid , Evere Acute Respiratory , Evere Acute Respiratory Syndrome , படம் கடன் , இல் விட்ரோ ,

Inhibition of nsp14 methyltransferase as a potential antiviral target for SARS-CoV-2

Beyond vaccination, the broad-spectrum antiviral medication remdesivir has robust clinical evidence and is known as the best antiviral treatment to reduce severe COVID-19 infection in hospitalized patients. Research led by John F.X. Diffley of the Chromosome Replication Laboratory suggests a potential therapeutic target for treatment development is the viral RNA cap methyltransferases, essential for viral protein translation and immune evasion. ....

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Researchers work to develop dual antigen COVID-19 vaccine candidate

A new study has been published on the medRxiv preprint server, which focuses on the development of a dual-antigen COVID-19' T cell' vaccine. This vaccine is developed based on the expression of both S protein and nucleocapsid (N) protein of SARS-CoV-2, using a next-generation human adenovirus serotype 5 (Ad5) platform. ....

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Researchers unveil new SARS-CoV-2 inhibitor that targets viral immune evasion

Researchers unveil new SARS-CoV-2 inhibitor that targets viral immune evasion
In a recent quest for an effective antiviral compound, UK researchers have purified a specific enzyme of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) known as nsp15 and optimized fluorescent biochemical endoribonuclease assays to screen a custom chemical library with over 5,000 commercial compounds. The study is currently available on the
bioRxiv preprint server
.
SARS-CoV-2 is a causative agent of coronavirus disease 2019 (COVID-19), a human disease that resulted in millions of deaths, burdened global health systems to near-breaking point, and imperiled economies of countries and families in an unprecedented fashion.
Although vaccination endeavors are well underway, not all countries can access them, and specific antiviral treatments to combat this disease are currently lacking. Remdesivir is the only antiviral drug approved for the treatment of COVID-19; howeve ....

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