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Chromatin-regulating enzyme found to be a key driver of common lung cancer


Chromatin-regulating enzyme found to be a key driver of common lung cancer
A chromatin-regulating enzyme has been shown by in-depth interdisciplinary investigations to be a key driver of a common type of lung cancer. Drugs that target the enzyme could improve treatment and survival rates for this particular cancer.
Squamous cell carcinoma represents nearly one third of all lung cancers in humans, says KAUST structural biologist Lukasz Jaremko, who led the research along with colleagues at Stanford University and The University of Texas MD Anderson Cancer Center, U.S. Our joint structural and dynamics investigations, including enzymatic activity studies, genetic analyses, and mouse model and human cell results, all point to the enzyme histone-lysine N-methyltransferase (NSD3) as a main driver of cancer, he says. ....

United States , Lukasz Jaremko , Vladlena Kharchenko , Emily Henderson , University Of Texas Md Anderson Cancer Center , Stanford University , Cancer Center , Lung Cancer , Squamous Cell Carcinoma , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , ஸ்டான்போர்ட் பல்கலைக்கழகம் , புற்றுநோய் மையம் , நுரையீரல் புற்றுநோய் ,