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Novel protein construct prevents lethal COVID-19 in mice


Novel protein construct prevents lethal COVID-19 in mice
Researchers in the United States have developed a novel protein that prevented lethal disease among mice infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).
The team engineered a soluble, short, and dimeric version of the native host cell receptor that is bound by a surface structure on SARS-CoV-2 called spike during the initial stage of the infection process.
The team – from the Feinberg School of Medicine in Chicago, the University of Chicago, and Northwestern University in Evanston – suspected that a soluble, truncated version of this membrane-bound receptor – called angiotensin-converting enzyme 2 (ACE2) – would serve as a decoy for SARS-CoV-2 spike binding and potentially neutralize infection. ....

United States , University Of Chicago , Daniel Batlle , Sally Robertson , Feinberg School Of Medicine , Northwestern University In Evanston , Feinberg School , Northwestern University , Angiotensin Converting Enzyme 2 , Binding Affinity , Corona Virus , Coronavirus Disease Covid 19 , In Vitro , In Vivo , Mouse Model , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் சிகாகோ , சாலி ராபர்ட்சன் , ஃபைன்பெர்க் பள்ளி ஆஃப் மருந்து , வடமேற்கு பல்கலைக்கழகம் இல் எவன்ஸ்டன் , ஃபைன்பெர்க் பள்ளி , வடமேற்கு பல்கலைக்கழகம் , பிணைப்பு இன உறவு ,

Study could lead to the development of novel treatments for drug-resistant cancers


Study could lead to the development of novel treatments for drug-resistant cancers
ETC-159, a made-in-Singapore anti-cancer drug that is currently in early phase clinical trials for use in a subset of colorectal and gynecological cancers, could also prevent some tumors from resisting therapies by blocking a key DNA repair mechanism, researchers from Duke-NUS Medical School and the Agency for Science, Technology and Research (A STAR) in Singapore reported in the journal
EMBO Molecular Medicine.
Among the many therapies used to treat cancers, inhibitors of the enzyme poly (ADP ribose) polymerase (PARP) prevent cancer cells from repairing naturally occurring DNA damage, including unwanted/harmful breaks in the DNA. When too many breaks accumulate, the cell dies. ....

Ann Lee , David Virshup , Emily Henderson , Agency For Science , Experimental Drug Development Centre , Assistant Professor Babita Madan , Stem Cell Biology , Professor David Virshup , Dna Damage , Medical School , Stem Cells , Wnt Signalling , ஆண்டு லீ , எமிலி ஹென்டர்சன் , சோதனை மருந்து வளர்ச்சி மையம் , உதவியாளர் ப்ரொஃபெஸர் பாபிடா மதன் , தண்டு செல் உயிரியல் , டீயெநே சேதம் , மருத்துவ பள்ளி , தண்டு செல்கள் ,

Study investigates activity of enzymes immobilized on gold nanoparticles controlled by infrared laser irradiation


Study investigates activity of enzymes immobilized on gold nanoparticles controlled by infrared laser irradiation
The activity of enzymes in industrial processes, laboratories, and living beings can be remotely controlled using light. This requires their immobilization on the surface of nanoparticles and irradiation with a laser. Near-infrared light can penetrate living tissue without damaging it.
The nanoparticles absorb the energy of the radiation and release it back in the form of heat or electronic effects, triggering or intensifying the enzymes catalytic activity. This configures a new field of study known as plasmonic biocatalysis.
Research conducted at the University of São Paulo s Chemistry Institute (IQ-USP) in Brazil investigated the activity of enzymes immobilized on gold nanoparticles controlled by infrared laser irradiation. An article reporting the results is published in ....

United States , Roberto Manuel Torresi , Emily Henderson , Paulo Research Foundation , Paulo Chemistry Institute , American Chemical Society , Chemistry Institute , American Chemical , Heloise Ribeiro De Barros , Thematic Project , Roberto Manuel , Ribeiro De Barros , Study Lead Author , Gold Nanoparticles , Transmission Electron Microscope , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , பாலொ ஆராய்ச்சி அடித்தளம் , பாலொ வேதியியல் நிறுவனம் , அமெரிக்கன் இரசாயன சமூகம் , வேதியியல் நிறுவனம் , அமெரிக்கன் இரசாயன , ஹெலோயிஸ் ரிபேீரோ டி பாரோஸ் , கருப்பொருள் ப்ராஜெக்ட் , ரொபெர்டோ மானுவல் , ரிபேீரோ டி பாரோஸ் ,

Researchers explore difference in reactions to SARS-CoV-2 infection between children and adults


Researchers explore difference in reactions to SARS-CoV-2 infection between children and adults
The coronavirus disease 2019 (COVID-19) pandemic has claimed over 2.67 million lives in less than a year and a half. However, it is uncommon in children, with less than 2% of the cases being in individuals below the age of 19. Most of these are of mild severity, with the clinical features of severe COVID-19 being rare in this age group.
A new and timely study, which was released on the
medRxiv preprint server, explores the differences in the response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in adults vs. children to help understand how the disease develops and progresses. ....

Liji Thomas , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Immune Response , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , கொரோனா வைரஸ் , நோய் எதிர்ப்பு சக்தி பதில் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

New research proposes innovative antibody-based treatment to prevent SARS-CoV-2 viral entry


New research proposes innovative antibody-based treatment to prevent SARS-CoV-2 viral entry
A brief report by researchers at the University of Virginia, USA, proposes using an antibody-based treatment with a plug-and-play strategy to inhibit the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to invade human cells.
The spike protein of SARS-CoV-2 binds with angiotensin-converting enzyme 2 (ACE2) receptors found on human cells, allowing it to gain entry and take over the cell’s machinery for replication.
The treatment results show it works by blocking the host protease-activation function of the spike protein one of the first steps needed for viral entry. ....

United States , Jocelyn Solis Moreiramar , Jocelyn Solis Moreira , University Of Virginia , Coronavirus Disease Covid 19 , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Corona Virus , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , ஒன்றுபட்டது மாநிலங்களில் , ஜாஸ்லைந் ஸோலிஸ் மோர்ர , பல்கலைக்கழகம் ஆஃப் வர்ஜீனியா , கொரோனா வைரஸ் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,