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Learning how to control HIV from African geno

A study on almost four thousand people of African descent has identified a gene that acts as natural defense against HIV by limiting its replication in certain white blood cells. An international effort co-led by EPFL, Canada’s National Microbiology Laboratory, and Imperial College London, it paves the way for new treatment strategies and underscores the importance of studying diverse ancestral populations to better address their specific medical needs and global health disparities. ....

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Gene Editing Expands to New Types of Immune Cells


Gene Editing Expands to New Types of Immune Cells
Gladstone researchers fine-tuned CRISPR-Cas9 genome editing to work on human immune cells called monocytes
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SAN FRANCISCO, May 11, 2021 /PRNewswire/ In the decade since the advent of CRISPR-Cas9 gene editing, researchers have used the technology to delete or change genes in a growing number of cell types. Now, researchers at Gladstone Institutes and UC San Francisco (UCSF) have added human monocytes white blood cells that play key roles in the immune system to that list.
A team of scientists at Gladstone Institutes and UC San Francisco led by Alex Marson (left) and Nevan Krogan (right) fine-tuned CRISPR-Cas9 genome editing to help understand how the human immune system fights viruses and microbes. ....

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