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Dual-Ligand-Modified Liposomes for Inhibiting Metastasis


In vitro Cytotoxicity Assays
Tumor angiogenesis promotes HCC development and metastasis. To investigate the in vitro cytotoxicity of different drug formulations, both MTT and Live/Dead assay were carried out on two-level cell culture systems (Figure 4C,
Supporting Figure 1): BEL7402 cells alone or BEL7402/HUVEC co-cultured cells. As shown in Figure 4Dand E, all drug treatment groups showed concentration-dependent cytotoxicity against BEL7402 cells and co-cultured system. Meanwhile, the CUCA/GA&Gal-Lip exhibited higher toxicity than CUCA/Lip and CUCA/Gal-Lip. It might be attributed to the stronger liver-targeting capability of dual-ligand-modified Lip, which was shown in the cellular uptake analysis (Figure 3). Interestingly, the IC ....

United States , Malvern Zetasizer Nano , Xian Ruixi Biological Technology Co Ltd , Biotechnology Research Institute , Jinan Pengyue Lab , Preparation Of Co , Aladdin Chemistry Co , Innochem Co Ltd , Aladdin Chemistry , Animal Experiment Ethics Committees , Weifang Medical University , Animal Management Rules , Co Loaded Lip Modified , Drug Release , Metastasis Model , Various Liposomal , Gal Modified Lip , ஒன்றுபட்டது மாநிலங்களில் , உயிரி தொழில்நுட்பவியல் ஆராய்ச்சி நிறுவனம் , விலங்கு மேலாண்மை விதிகள் , மருந்து வெளியீடு ,

PFOB@LIP-Tet to treat dry eye disease


8 Cytokines, including Il-1β, TNF-α, and PEG
2 and VEGF, have been certified to play an important role in DED, and by inhibiting expression of those cytokines, symptoms of DED could be significantly alleviated.
35–39 Traditional anti-inflammatory agents like corticosteroids would result in disastrous incidence if inappropriately applied, including intraocular hypertension and cataract,
10 which narrows its use in DED therapy. Therefore, an effective anti-inflammation agent with less impact on intraocular pressure is worthy of exploration. Tet, a plant alkaloid isolated from a traditional Chinese herb,
11 is initially used as an anti-inflammation agent to treat rheumatoid arthritis. It has been demonstrated that Tet could suppress the release of IL-1β, TNF-α, VEGF and PEG ....

South Korea , United States , Corden Liestal , Zealand White , Statens Seruminstitut , Allergan Inc , Becton Dickinson , Ruixi Biological Technology Xian , Animal Ethics Committee Of Chongqing Medical University , Animal Ethics Committee , Observations Of Physicochemical Properties Liposomes , Ccri Inc , Animal Research Center , Graphpad Software , University Animal Research Center , Aldrich Co , Ruixi Biological Technology , Shanchuan Biotechnology , Fine Biotech , Physicochemical Properties , Tet Loading , Its Release , New Zealand White , Chongqing Medical University , Chongqing Medical , Cell Counting ,

Gaoyou: The Chinese county famed for double-yolk duck eggs


Megan Zhang, CNN • Updated 14th May 2021
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(CNN) Would you like salted duck egg with that? asked the cook.
I was on a trip to Yangzhou in China s Jiangsu province and had popped into a small eatery for a bite of breakfast, ordering congee and a side of pickled vegetables.
Before I could respond, the cook disappeared into the kitchen, then reemerged holding a grayish-green egg balanced on a plate.
Sure, I nodded.
Plain congee, after all, pairs best with sour or pungent condiments that pack a lot of punch. And in my experience, the sharp flavor of salted duck eggs cured in brine to produce salty whites and rich, creamy yolks could be even more stimulating than a cup of joe. ....

Meng Wen , United States , Yuan Mei , Inner Mongolia Autonomous Region , Nei Mongol , Grand Canal , China General , Meng Delong Xinhua Getty , Sharyne Moy Tu , Miranda Brown , David Yan , Seanjs Chen , Li Bo Xinhua Sipa , Imaginechina Limited Alamy , Jiangsu Gaoyou Duck Co , University Of Michigan , Courtesy Sharyne Moy , Wild China , Gaoyou Lake , Jiangsu Gaoyou Duck , Sipa United , Getty Images , Aoyou The Chinese County Famed For Double Yolk Duck Eggs Cnn , மெங் வென் , ஒன்றுபட்டது மாநிலங்களில் , யுவான் மெய் ,