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TCR transgenic clone selection guided by immune receptor analysis and single cell RNA expression of polyclonal responders

TCR transgenic clone selection guided by immune receptor analysis and single cell RNA expression of polyclonal responders
elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.

Bioanalyzer Agilent , Novocyte Quanteon , Graphpad Software Inc , Jackson Laboratory , Tree Star Inc , Ghent University , Abbott Laboratories , Spike Epitope , Spike Tetramer , Cell Tracer Violet , Representative Flowjo , Janvier Labs , Cell Isolation Kit , Cell Proliferation Dye , Thermo Fisher Scientific , European Virus Archive , Biosafety Level , Beads Counting , Tree Star , Graphpad Prism , Graphpad Software , Core Facility , Chromium Gemcode Single Cell Instrument , Gemcode Single Cell , Gel Bead , Illumina Novaseq ,

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

Discoverx Pathhunter , Tocris Bioscience , Norbinaltorphimine Nor , Harlan Sprague Dawley , Association For Assessment , Associates Inc , Scripps Research Institute Jupiter , Accreditation Of Laboratory Animal Care , Analysis Software , Wake Forest School Of Medicine Winston Salem , Jackson Laboratory , Scripps Research Institute , Graphpad Software , National Institutes Of Health Animal Care , Drug Supply Program , National Institute , Drug Abuse , National Institutes , Arrestin Cell Line , Graphpad Prism , Laboratory Animal Care , Scripps Research , Health Animal Care , Wake Forest School , Institutional Animal Care , Vashaw Scientific ,

Microglial cell response to experimental periodontal disease | Journal of Neuroinflammation

Microglial activation is critical for modulating the neuroinflammatory process and the pathological progression of neurodegenerative diseases, such as Alzheimer's disease (AD). Microglia are involved in forming barriers around extracellular neuritic plaques and the phagocytosis of β-amyloid peptide (Aβ). In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells. Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Maxillary bone loss and local periodontal tissue inflammation associated with the development of PD were confirmed by morphometric bone analysis and cytokine expression, respectively. The frequency and the total number of activated microglia (CD45+ CD11b+ MHCII+) in the brain were analyzed by flow cytometry. Mouse m ....

United States , La Jolla , San Diego , Miltenyi Biotec , Dnasei Zymo Research , Hbss Rd Systems Inc , Sigma Aldrich , Graphpad Software , Roswell Park Memorial Institute , Graphpad Prism Software , Committee Of The Forsyth Institute , Institutional Animal Care , Use Committee , Forsyth Institute , Life Technologies , Thermofisher Scientific , Transcription Kit , Applied Biosystems , Steponeplus Real Time , Fast Advanced Master Mix , Taqman Gene Expression Assays , Zymo Research , Fetal Bovine Serum , Fixable Viability Kit , Distributed Stochastic Neighbor Embedding , Soy Agar ,

mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent

mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

United States , Supermix Bio Rad , Qiagen Rneasy , Cleancap Trilink , Mann Whitney Welch , Yale University Institutional Animal Care , Zetasizer Nano Zs Malvern Instruments Ltd , Alexandra Cohen Foundation , Yale University , Graphpad Software , Centers For Disease , Simple Modular Architecture Research Tool , Oklahoma State University , Ge Healthcare Life Sciences , Yale Center , North America , Disease Control , Kyoto Encyclopedia , Laboratory Animals , National Institutes , Use Committee , Animal Protocol , Biosafety Level , Charles River Laboratories , Zetasizer Nano , Malvern Instruments Ltd ,

Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity

Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity
elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.

France General , United States , United Kingdom , Eteläuomen Läi , Foster City , San Diego , Nordrhein Westfalen , Katharina Iben , Anna Judycka , Kerstin Stemmer , Janh Britsemmer , Pault Pfluger , Ingolf Cascorbi , Meike Kaehler , Jonas Wagner , Sonjac Schriever , Natalie Taege , Christin Krause , Henriette Kirchner , Hendrik Lehnert , Oliver Mann , Anna Molenaar , Katrin Huber , Miriam Bernecker , Akt Ser , Stefan Wolter ,