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8 Cytokines, including Il-1β, TNF-α, and PEG
2 and VEGF, have been certified to play an important role in DED, and by inhibiting expression of those cytokines, symptoms of DED could be significantly alleviated.
35–39 Traditional anti-inflammatory agents like corticosteroids would result in disastrous incidence if inappropriately applied, including intraocular hypertension and cataract,
10 which narrows its use in DED therapy. Therefore, an effective anti-inflammation agent with less impact on intraocular pressure is worthy of exploration. Tet, a plant alkaloid isolated from a traditional Chinese herb,
11 is initially used as an anti-inflammation agent to treat rheumatoid arthritis. It has been demonstrated that Tet could suppress the release of IL-1β, TNF-α, VEGF and PEG ....

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