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RNA inhibitor is shown safe and effective in reducing a wide range of cholesterol and triglyceride levels in the blood

A small interfering RNA (siRNA) investigational therapy that inhibits a gene involved in lipoprotein metabolism has been shown in a clinical trial led by Mount Sinai researchers to significantly reduce levels of different types of cholesterol and triglycerides in individuals with mixed hyperlipidemia, a condition in which fats build up in the blood.

France
Roberts-rosenson
Robert-rosenson
Drug-administration
Metabolism-for-the-mount-sinai-health-system
Zodasiran-arrowhead-pharmaceuticals
Icahn-school-of-medicine-at-mount-sinai
European-atherosclerosis-society-congress-on
Mount-sinai
European-atherosclerosis-society-congress
New-england-journal
Arrowhead-pharmaceuticals

Promising Hyperlipidemia Treatment Lowers Cardiovascular Risk

Promising Hyperlipidemia Treatment Lowers Cardiovascular Risk
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Texas
United-states
Baylor-college-of-medicine
Roberts-rosenson
Jennifer-hellawell
Daniel-gaudet
Rong-zhou
Maan-mushin
Peter-clifton
Nicholasj-leeper
Christie-ballantyne
Stacey-melquist

Extended Zerlasiran Data Show Sustained Lp(a) Reduction

The experimental siRNA agent led to prolonged Lp(a) reduction of more than 90%, extended data from the phase 1 trial show, supporting the move to phases 2 and 3 trials.

New-york
United-states
Cleveland
Ohio
Stevene-nissen
Roberts-rosenson
Icahn-school-of-medicine-at-mount-sinai
Cleveland-clinic
Silence-therapeutics
Icahn-school
Mount-sinai

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