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RNA inhibitor is shown safe and effective in reducing a wide range of cholesterol and triglyceride levels in the blood

A small interfering RNA (siRNA) investigational therapy that inhibits a gene involved in lipoprotein metabolism has been shown in a clinical trial led by Mount Sinai researchers to significantly reduce levels of different types of cholesterol and triglycerides in individuals with mixed hyperlipidemia, a condition in which fats build up in the blood. ....

France , Roberts-rosenson , Robert-rosenson , Drug-administration , Metabolism-for-the-mount-sinai-health-system , Zodasiran-arrowhead-pharmaceuticals , Icahn-school-of-medicine-at-mount-sinai , European-atherosclerosis-society-congress-on , Mount-sinai , European-atherosclerosis-society-congress , New-england-journal , Arrowhead-pharmaceuticals

Promising Hyperlipidemia Treatment Lowers Cardiovascular Risk

Promising Hyperlipidemia Treatment Lowers Cardiovascular Risk
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Extended Zerlasiran Data Show Sustained Lp(a) Reduction

The experimental siRNA agent led to prolonged Lp(a) reduction of more than 90%, extended data from the phase 1 trial show, supporting the move to phases 2 and 3 trials. ....

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RNA interference therapies safely lower atherosclerotic cholesterol

RNA interference therapies safely lower atherosclerotic cholesterol
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