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"Christchurch Mutation" – How Good Can Overpower Evil in Alzheimer's Disease Genetics

New research sheds light on protective mechanisms of the “Christchurch mutation.” Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the “Christchurch mutation” can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most co ....

Universidad De Antioquia , New Zealand , United States , Reuben Thomas , Tenzing Choenyi , Josephf Arboleda Velasquez , Oscar Yip , Yakeelt Quiroz , Robertw Mahley , Eric Reiman , Jessica Blumenfeld , Seo Yeon Yoon , Robert Mahley , Maxiner Nelson , Michela Traglia , Joseph Arboleda Velasquez , Brian Grone , Joo Kim , Aayushi Agrawal , Maxine Nelson , Nicole Koutsodendris , Yanxia Hao , Yakeel Quiroz , Peng Liu , Francisco Lopera , Yadong Huang ,

Study on largest genetic risk factor for Alzh

<p>Scientists at Gladstone Institutes have discovered that APOE4-producing neurons release an immune signaling molecule called HMGB1 at much higher rates than neurons producing other APOE variants. Upon release, HMGB1 activates brain immune cells called microglia, which then trigger inflammation and the degeneration of neurons.</p>
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Mission Bay , United States , San Francisco , Oscar Yip , Nicole Koutsodendris , Yanxia Hao , Seo Yeon Yoon , Misha Zilberter , Patrick Arriola , Michela Traglia , Maxiner Nelson , Reuben Thomas , Antara Rao , Yadong Huang , Aayushi Agrawal , Jessica Blumenfeld , Yung Hua Wang , Joo Kim , Brian Grone , Gabaeron Inc , University Of California , Method Of Research , National Institutes Of Health , Gladstone Institutes , Cell Reports , Gladstone Investigator ,

Impact of Key Alzheimer's Protein Depends on Type of Brain Cell in Which It Is Produced

/PRNewswire/ Of all the known genetic risk factors for late-onset Alzheimer s disease, the strongest is a gene for the protein called ApoE4. People with one. ....

United States , Mission Bay , San Francisco , Yanxia Hao , Julie Langelier , Seo Yeon Yoon , Misha Zilberter , Nicole Koutsodendris , Antara Rao , Jessica Blumenfeld , Yadong Huang , Patrick Arriola , Oscar Yip , Michela Traglia , Aayushi Agrawal , Maxiner Nelson , Reuben Thomas , Brian Grone , A New Direction For Drug Development , National Institute On Aging , Gladstone Institutes , Nature Aging , Gladstone Senior Investigator , North Americans , Translational Advancement , Stem Cell Biology ,