<p>Scientists at Gladstone Institutes have discovered that APOE4-producing neurons release an immune signaling molecule called HMGB1 at much higher rates than neurons producing other APOE variants. Upon release, HMGB1 activates brain immune cells called microglia, which then trigger inflammation and the degeneration of neurons.</p>
Researchers at Gladstone Institutes and UC San Francisco (UCSF) have shed new light on exactly how neurons the cells that send electrical signals through the brain consume and metabolize glucose, as well as how these cells adapt to glucose shortages. These findings could have implications for understanding neurodegenerative diseases.
/PRNewswire/ The human brain has a sweet tooth, burning through nearly one quarter of the body s sugar energy, or glucose, each day. Now, researchers at.
/PRNewswire/ Of all the known genetic risk factors for late-onset Alzheimer s disease, the strongest is a gene for the protein called ApoE4. People with one.
/PRNewswire/ The race to develop drugs to treat Alzheimer s disease, which currently affects an estimated 6 million Americans, has been slow-going. Now,.