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"Christchurch Mutation" – How Good Can Overpower Evil in Alzheimer's Disease Genetics

New research sheds light on protective mechanisms of the “Christchurch mutation.” Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the “Christchurch mutation” can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most co ....

Universidad De Antioquia , New Zealand , United States , Reuben Thomas , Tenzing Choenyi , Josephf Arboleda Velasquez , Oscar Yip , Yakeelt Quiroz , Robertw Mahley , Eric Reiman , Jessica Blumenfeld , Seo Yeon Yoon , Robert Mahley , Maxiner Nelson , Michela Traglia , Joseph Arboleda Velasquez , Brian Grone , Joo Kim , Aayushi Agrawal , Maxine Nelson , Nicole Koutsodendris , Yanxia Hao , Yakeel Quiroz , Peng Liu , Francisco Lopera , Yadong Huang ,

Cyril Amarchand Mangaldas advises Zurich Insurance on acquisition of majority stake in Kotak Mahindra General Insurance

BusinessWire India Mumbai (Maharashtra) [India], November 2: Cyril Amarchand Mangaldas acted as a legal counsel to Zurich Insurance Company Ltd on its proposed acquisition of a majority stake from Kotak Mahindra Bank Limited in Kotak Mahindra General Insurance Company Limited. The transaction team was led by Indranath Bishnu, Partner; with support from Anirud Sudarsan R., Principal Associate; and Ayushi Agrawal, Associate. The CAM team advised on Indian legal and regulatory framework in relation to foreign shareholding in an Indian insurance company, including the foreign exchange regulations, conducting due diligence on Kotak Mahindra General Insurance Company Limited, drafting and advising on transaction documents and general advisory in relation to required regulatory approvals for the proposed transaction in India. The due diligence team was led by Indranath Bishnu, Partner; with support from Anirud Sudarsan R., Principal Associate; Shaleen Tiwari, Senior Associate, Ila Vyas, Senio ....

New Jersey , United States , New York , Civil Aviation Administration Of China , Walgreens Boots Alliance , Health Corp , Civil Aviation Administration , Businesswire India Mumbai Maharashtra , Ovember 2 Cyril Amarchand Mangaldas Acted Asa Legal Counsel To Zurich Insurance Company Ltd On Its Proposed Acquisition Ofa Majority Stake From Kotak Mahindra Bank Limited In General The Transaction Team Was Led By Indranath Bishnu , Artner With Support From Anirud Sudarsanr , Rincipal Associate And Ayushi Agrawal , Ssociate The Cam Team Advised On Indian Legal And Regulatory Framework In Relation To Foreign Shareholding An Insurance Company , Ncluding The Foreign Exchange Regulations , Onducting Due Diligence On Kotak Mahindra General Insurance Company Limited , Rafting And Advising On Transaction Documents General Advisory In Relation To Required Regulatory Approvals For The Proposed India Due Diligence Team Was Led By Indranath Bishnu , Rincipal Associate Shaleen Tiwari , Senior Associate , La Vyas , Soumyaditya Dasgupta , Senior Associate Designate , Aayushi Agrawal , Ssociate Mohini Parghi , Aryan Wasnik , Ssociate Ankita Ray , Artner With Support From Krithika Radhakrishnan , Rincipal Associate And Siddhi Kochar ,

Study on largest genetic risk factor for Alzh

<p>Scientists at Gladstone Institutes have discovered that APOE4-producing neurons release an immune signaling molecule called HMGB1 at much higher rates than neurons producing other APOE variants. Upon release, HMGB1 activates brain immune cells called microglia, which then trigger inflammation and the degeneration of neurons.</p>
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Mission Bay , United States , San Francisco , Oscar Yip , Nicole Koutsodendris , Yanxia Hao , Seo Yeon Yoon , Misha Zilberter , Patrick Arriola , Michela Traglia , Maxiner Nelson , Reuben Thomas , Antara Rao , Yadong Huang , Aayushi Agrawal , Jessica Blumenfeld , Yung Hua Wang , Joo Kim , Brian Grone , Gabaeron Inc , University Of California , Method Of Research , National Institutes Of Health , Gladstone Institutes , Cell Reports , Gladstone Investigator ,