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SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction

SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction
elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.

United States , Palo Alto , Franklin Lakes , Vilardo Rossmanith , Ubiquitinc Fisher , Zeiss Axioscan , Roberts Barnard , Agilent Tapestation , Eli Lilly , Faxitron Biovision , Thermo Fisher , Oxymax Comprehensive Laboratory Animal Monitoring System , Vivo Muscle Max Force Generation , Mettler Toledo , Sigma Aldrich , Illumina Control Software , Library Prep Kit For Illumina , Aurora Scientific Inc , Research Diets , Imagej Software , Sigma Chemical Company , Carl Zeiss , Electron Microscopy Sciences , Fisher Scientific , Biodaq Food , Dutch Hunger ,

Apoptotic stress causes mtDNA release during senescence and drives the SASP

Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP)1. Mitochondria are major regulators of the SASP; however, the underlying mechanisms have not been elucidated2. Mitochondria are often essential for apoptosis, a cell fate distinct from cellular senescence. During apoptosis, widespread mitochondrial outer membrane permeabilization (MOMP) commits a cell to die3. Here we find that MOMP occurring in a subset of mitochondria is a feature of cellular senescence. This process, called minority MOMP (miMOMP), requires BAX and BAK macropores enabling the release of mitochondrial DNA (mtDNA) into the cytosol. Cytosolic mtDNA in turn activates the cGAS–STING pathway, a major regulator of the SASP. We find that inhibition of MOMP in vivo decreases inflammatory markers and improves healthspan in aged mice. Our results reveal that apoptosis and senescence are regulated by similar mitochondria-depende ....

United Kingdom , Adooq Biosciences , Tocris Bioscience , Antifade Mountant , Gencode Grch , Bruker Ct , Rnalater Qiagen , Dynabeads Invitrogen , Skyscan Nrecon , Zeiss Airyscan , Octo Dissociator Miltenyi , Analysis Software , Imol Polish Academy Of Sciences , Huygens Deconvolution Software , University Of Glasgow Animal Welfare , Pall Corporation , Thermo Fisher , National Institute On Aging , United Kingdom Home Office , Thermo Fisher Scientific , Atlanta Biological , Absolute Human Mitochondrial , Number Quantification , Tissue Kit , Qiaquick Nucleotide Removal Kit , Agilent Seahorse ,

Metabolic and Neurobehavioral Disturbances Induced by Purine Recycling Deficiency in Drosophila

Metabolic and Neurobehavioral Disturbances Induced by Purine Recycling Deficiency in Drosophila
elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.

United States , France General , Baden Wüberg , Saint Jean Dillac , La Jolla , Bad Wildbad , San Diego , Montigny Le Bretonneux , Thomas Riemensperger , Labex Memolife , Packard Tri Carb , Takara Bio , Santa Clara , Downregulating Aprt , Smith Friedman , States Cichewicz , Administration Of Adenosine , Bloomington Drosophila Stock Center , Trikinetics Inc , Graphpad Software , Waters Corporation , Association Malaury , Sigma Aldrich , Research University , Vienna Drosophila Resource Center , Drosophila Genomics Resource Center ,

lncRNA DRAIC and miR-3940-3p in lung adenocarcinoma

The clinical significance and biological function of lncRNA DRAIC and miR-3940-3p in LUAD were assessed in this study. ....

Eteläuomen Läi , United States , Pearson Chi Square , World Medical Association Declaration Of Helsinki , First Affiliated Hospital Of China Medical University , Ethics Committee , First Affiliated Hospital , China Medical University , International Association , Lung Cancer , World Medical Association Declaration , Lines Culture , Dual Luciferase Reporter , Dual Luciferase Reporter Assay System , Quantitative Real Time Polymerase Chain Reaction , Lysis Reagent , Extraction Kit , Transcription Kit , Applied Biosystems , Proliferation Accessed , Cell Counting , Thermo Fisher Scientific , Invasion Determined , Were Detected , Unfavorable Prognosis , Regression Analysis ,