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Exploring Key Topics in Sample Quality Control for NGS Workflows on SelectScience

Watch the latest scientific webinars on SelectScience. ....

Agilent Tapestation , Agilent Technologies , Decode Health , Exploring Key Topics , Sample Quality Control , Analyzing High Molecular Weight , Pacbio Hifi Long Read Sequencing Services , Agilent Femto Pulse , Femto Pulse , Garbage Out , End To Quality Control Processes ,

Correlate NGS success with sample input quality

Explore how the DNA integrity number can be used to differentiate between samples of different quality ....

Agilent Tapestation , Application Note , Agilent Genomic , Automated Electrophoresis ,

Nuclear export of circular RNA

Circular RNAs (circRNAs), which are increasingly being implicated in a variety of functions in normal and cancerous cells1–5, are formed by back-splicing of precursor mRNAs in the nucleus6–10. circRNAs are predominantly localized in the cytoplasm, indicating that they must be exported from the nucleus. Here we identify a pathway that is specific for the nuclear export of circular RNA. This pathway requires Ran-GTP, exportin-2 and IGF2BP1. Enhancing the nuclear Ran-GTP gradient by depletion or chemical inhibition of the major protein exporter CRM1 selectively increases the nuclear export of circRNAs, while reducing the nuclear Ran-GTP gradient selectively blocks circRNA export. Depletion or knockout of exportin-2 specifically inhibits nuclear export of circRNA. Analysis of nuclear circRNA-binding proteins reveals that interaction between IGF2BP1 and circRNA is enhanced by Ran-GTP. The formation of circRNA export complexes in the nucleus is promoted by Ran-GTP through its int ....

Agilent Tapestation , Cell Profiler , Total Ran ,

Quality control of cell-free DNA samples analyzed with NGS

Agilent discusses how to assess the quality of cell-free DNA samples analyzed with next-generation sequencing ....

Agilent Tapestation , Application Note , Na Screentape ,

nRichDX to Exhibit at the Association for Molecular Pathology (AMP) 2023 Annual Meeting & Expo

/PRNewswire/ The Association for Molecular Pathology 2023 Annual Meeting & Expo will be held 14-18 November 2023 at the Salt Palace Convention Center in. ....

Salt Palace Convention Center , United States , Salt Lake City , Agilent Tapestation , Tom Curtis , Greg Tsongalis , Association For Molecular Pathology , Hitchcock Medical Center , Agilent Technologies , Revolution Sample Prep System , Molecular Pathology , Salt Lake , Link Between Total , Downstream Assays , Sample Prep System , Liquid Biopsy , Innovation Spotlight Stage , Expo Hall , Revolution System , Shiva Sathyanarayana , Vice Chair , Medical Director , Clinical Genomics , Advanced Technology , Dartmouth Hitchcock Medical , Epithelial Origin ,