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Apoptotic stress causes mtDNA release during senescence and drives the SASP

Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP)1. Mitochondria are major regulators of the SASP; however, the underlying mechanisms have not been elucidated2. Mitochondria are often essential for apoptosis, a cell fate distinct from cellular senescence. During apoptosis, widespread mitochondrial outer membrane permeabilization (MOMP) commits a cell to die3. Here we find that MOMP occurring in a subset of mitochondria is a feature of cellular senescence. This process, called minority MOMP (miMOMP), requires BAX and BAK macropores enabling the release of mitochondrial DNA (mtDNA) into the cytosol. Cytosolic mtDNA in turn activates the cGAS–STING pathway, a major regulator of the SASP. We find that inhibition of MOMP in vivo decreases inflammatory markers and improves healthspan in aged mice. Our results reveal that apoptosis and senescence are regulated by similar mitochondria-depende ....

United Kingdom , Adooq Biosciences , Tocris Bioscience , Antifade Mountant , Gencode Grch , Bruker Ct , Rnalater Qiagen , Dynabeads Invitrogen , Skyscan Nrecon , Zeiss Airyscan , Octo Dissociator Miltenyi , Analysis Software , Imol Polish Academy Of Sciences , Huygens Deconvolution Software , University Of Glasgow Animal Welfare , Pall Corporation , Thermo Fisher , National Institute On Aging , United Kingdom Home Office , Thermo Fisher Scientific , Atlanta Biological , Absolute Human Mitochondrial , Number Quantification , Tissue Kit , Qiaquick Nucleotide Removal Kit , Agilent Seahorse ,

MRE11-dependent instability in mitochondrial DNA fork protection activates a cGAS immune signaling pathway

MRE11-dependent instability in mitochondrial DNA fork protection activates a cGAS immune signaling pathway
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

United States , Biotek Gen , M Mitotracker Cmxros , Andor Zyla , Leica Ultracut , Mitotracker Cmxros , Rita Allen Foundation Fellowship , University Of Texas Md Anderson Cancer Center , Ab Cell Signaling Technology , Md Anderson Cancer Center , Rita Allen Foundation , United States Inc , Cell Signaling Technology , Research Institute Of Texas , Imaging System Advanced Microscopy Techniques Corp , Life Technologies , Gemini Bio Products , American Type Culture Collection , Thermo Fisher Scientific , Prolong Gold , Puregene Core , Master Mix , Alexa Fluor , Oregon Green , Novus Biologicals , Eclipse Ti U ,

IP3R-driven increases in mitochondrial Ca2+ promote neuronal death in NPC disease

IP3R-driven increases in mitochondrial Ca2+ promote neuronal death in NPC disease
pnas.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from pnas.org Daily Mail and Mail on Sunday newspapers.

United States , Oscar Vivas , Zeiss Airyscan , Ara Parseghian Medical Research Foundation , University Of California , Familial Alzheimer ,

Current and future advances in fluorescence-based visualization of plant cell wall components and cell wall biosynthetic machineries

Current and future advances in fluorescence-based visualization of plant cell wall components and cell wall biosynthetic machineries
biomedcentral.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from biomedcentral.com Daily Mail and Mail on Sunday newspapers.

Zeiss Airyscan , Pontamine Fast Scarlet ,