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Scientists solve decades long mystery of NLRC5 sensor function in cell death

A new study identifies NLRC5 as an innate immune sensor that plays a crucial role in PANoptotic cell death making it a key therapeutic target. ....

Balamurugan Sundaram , Thirumala Devi Kanneganti , Nagakannan Pandian , Jude Department Of Immunology , Jude Department ,

How tight binding between immune cells dictates T cell cancer-fighting ability

Immunotherapy, treatments that reinvigorate immune cells' anti-cancer activity or reprogram T cells to target cancer, has shown promise in treating leukemias but has not yet been realized in solid tumors. ....

Benjamin Youngblood , Jude Department Of Immunology , Jude Children Research Hospital , Jude Children , Research Hospital , Jude Department ,

'Goldilocks' binding strength determines anti-cancer T-cell efficacy and fate

Findings showed that how tight a parental T cell binds to a cancer-related protein determines whether its offspring will become functional anti-cancer effector cells or dysfunctional exhausted T cells. ....

Benjamin Youngblood , Jude Department Of Immunology , Jude Department ,