Researchers use epigenetic clock, DNA methylation and mouse model to demonstrate that T cell proliferation can stretch past organism lifespan and acuta lymphoblastic leukemia T cells appear hundreds of years old.
Immunotherapy, treatments that reinvigorate immune cells' anti-cancer activity or reprogram T cells to target cancer, has shown promise in treating leukemias but has not yet been realized in solid tumors.
Findings showed that how tight a parental T cell binds to a cancer-related protein determines whether its offspring will become functional anti-cancer effector cells or dysfunctional exhausted T cells.
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