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Age is just a number: Immune cell 'epigenetic clock' ticks independently of organism lifespan

Researchers use epigenetic clock, DNA methylation and mouse model to demonstrate that T cell proliferation can stretch past organism lifespan and acuta lymphoblastic leukemia T cells appear hundreds of years old.

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Goldilocks Binding Strength Dictates T-cell Cancer Battle Outcome

Goldilocks Binding Strength Dictates T-cell Cancer Battle Outcome
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Young vs. old: How host environment affects immune response

Benjamin Youngblood, Ph.D., and Ardiana Moustaki, Ph.D., of the St. Jude Department of Immunology. Most clinical studies of the immune system use

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Exhaustion affects CAR T-cell clinical response

L to R: Benjamin Youngblood, Ph.D.; Aimee Talleur, M.D.; Caitlin Zebley, M.D., Ph.D.; and Stephen Gottschalk, M.D. St. Jude Children’s Research

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