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'Three-way interaction' found between HLA-B27, male sex, sacroiliitis development in IBD

CHICAGO — In patients with inflammatory bowel disease, a “strong and consistent three-way interaction” was identified between HLA-B27, male sex and the development of sacroiliitis, according to data presented at Digestive Disease Week.Sacroiliitis occurs in approximately 20% of patients with IBD, often aligned with male sex and HLA-B27 status; however, large-scale studies on the ....

United States , Byrobert Stott , Dermot Mcgovern , Heather Biele , Inflammatory Bowel Disease Center , Immunobiology Research Institute At Cedars , Sinai Medical Center , Digestive Disease Week , Digestive Disease , Immunobiology Research Institute , Cedars Sinai Medical Center ,

New Study Sheds Light on the Cause of Severe Inflammatory Bowel Disease

Scientists at Cedars-Sinai have identified a genetic variant that is associated with perianal Crohn's disease. Investigators at Cedars-Sinai have discovered a genetic variant that elevates an individual's likelihood of experiencing perianal Crohn's disease, which is considered to be the most severe ....

United States , Lisas Thomas , Stevenr Brant , Hussein Hamade , Erica Vasiliauskas , Johnd Rioux , Shervin Rabizadeh , Gily Melmed , Davida Ziring , Williama Faubion , Nirupaman Bonthala , Lisaz Greer , Dalin Li , Gregoryj Botwin , Alkaa Potdar , Phillip Fleshner , L Philip Schumm , Marks Silverberg , Michelle Khrom , Ramachandran Murali , Richardh Duerr , Roberts Sandler , Judyh Cho , Emebet Mengesha , Carolj Landers , Ramnikj Xavier ,

New study sheds light on cause of severe inflammatory bowel disease

Perianal Crohn’s disease is a type of inflammatory bowel disease that affects the area around the anus. It can cause symptoms such as pain, itching and discharge, as well as more serious complications such as abscesses and fistulas. Scientists at Cedars-Sinai have identified a genetic mutation associated with perianal Crohn’s disease. Investigator Cedars Sinai […] ....

United States , Rodneyd Newbery , Ramnikj Xavier , Erica Vasiliuskas , Bana Jabri , Dermot Mcgovern , Emebet Mengesha , Roberts Sandler , R Balfour Sarter , Richardh Duer , Judyh Cho , Karen Zagyan , Kathrin Michelsen , Sergioa Lira , Michelle Khrom , Stephenr Targan , Talin Haritunians , Alkaa Potdar , L Phillip Shum , Shervin Rabizadeh , Williama Faubion , Kathryns Michaelsen , Marks Silverberg , Dalin Li , Nirupaman Bonsala , Perianal Crohn ,

Study offers more insight into causes of acute inflammatory bowel illness

Los Angeles (California), April 23: A genetic variation uncovered by Cedars-Sinai researchers increases the likelihood of getting perianal Crohn s disease, the most devastating type of Crohn s disease. ....

Los Angeles , United States , Talin Haritunians , Dermot Mcgovern , Kathrin Michelsen , Lisaz Greer , Perianal Crohn , Translational Research , Immunobiology Research Institute , Mcgovern Laboratory , Biomedical Sciences At Cedars , Sinaif Widjaja Foundation Inflammatory Bowel , Foundation Inflammatory Bowel , Inflammatory Bowel Disease , Biomedical Sciences , Grand Prix Paris Open , Study Offers More Insight Into Causes Of Acute Inflammatory Bowel Illness ,

Study offers more insight into causes of acute inflammatory bowel illness

A genetic variation uncovered by Cedars-Sinai researchers increases the likelihood of getting perianal Crohn s disease, the most devastating type of Crohn s disease. ....

United States , Perianal Crohn , Talin Haritunians , Lisaz Greer , Dermot Mcgovern , Kathrin Michelsen , Biomedical Sciences At Cedars , Immunobiology Research Institute , Sinaif Widjaja Foundation Inflammatory Bowel , Translational Research , Mcgovern Laboratory , Foundation Inflammatory Bowel , Inflammatory Bowel Disease , Biomedical Sciences , Ews India ,