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Neutrophil-to-lymphocyte ratio may aid diagnosis of infectious, idiopathic orbital disease

The neutrophil-to-lymphocyte ratio appeared to distinguish between acute orbital infectious disease and noninfectious inflammation and may aid in clinical intervention, according to a study in Ophthalmic Plastic and Reconstructive Surgery.
“The neutrophil-to-lymphocyte ratio (NLR) is a relatively new biomarker that measures the relative roles of the innate (via neutrophils) and adaptive ....

Bykate Young , Heather Biele , Edwardj Wladis , Albany Medical College , Ophthalmic Plastic ,

Bariatric surgery significantly reduced major adverse liver outcomes in MASH cirrhosis

At 15 years of follow-up, metabolic surgery “was not only safe” but also significantly reduced major adverse liver outcomes and decompensation in patients with metabolic dysfunction-associated steatohepatitis and compensated cirrhosis.“Previous studies suggested excellent clinical outcomes in patients with MASH and fibrosis stages 1 to 3 with improvement in both cardiac and ....

United States , Heather Biele , Bymonica Stonehill , Naim Alkhouri , Arizona Liver Health , Cleveland Clinical Health System , Advancing Long Term ,

'Substantial proportion' of PSC patients listed for LT due to dysplasia have no neoplasia

Researchers identified bile duct dysplasia or cancer in most explanted livers with an indication of biliary dysplasia, although as many as 41% had no signs of neoplasia, according to a study of patients with primary sclerosing cholangitis.
“Primary sclerosing cholangitis, in short PSC, is one of the leading causes of liver transplantation in the Nordic countries with a high risk of ....

Sigurd Breder , Heather Biele , Bykate Burba , Research Center , Nordic Liver Transplant Registry ,

GLP-1 receptor agonists 'have changed the playing field' in pediatric MASLD

WASHINGTON — Glucagon-like peptide-1 receptor agonists significantly reduced alanine aminotransferase levels in pediatric metabolic dysfunction-associated steatotic liver disease, especially those with type 2 diabetes, researchers reported.
“The study was prompted by my interest in the use of anti-obesity medications in the treatment of MASLD,” Jennifer A. Panganiban, MD, ....

United States , Heather Biele , Jennifera Panganiban , Saxenda Victoza , Byrobert Stott , Ozempic Wegovy , Novo Nordisk , Non Alcoholic Fatty Liver Disease Program , Pediatric Gastroenterology ,

Elafibranor has 'significant, sustained treatment benefit' in PBC through 78 weeks

Elafibranor sustained biochemical response through week 78 in patients with primary biliary cholangitis and has a “potential beneficial effect” on itch-related quality of life, according to late-breaking data presented at EASL Congress.“There is a major unmet need for a primary biliary cholangitis (PBC) treatment that effectively targets the biochemical indicators of disease ....

United States , Christelle Huguet , Bymonica Stonehill , Andrease Kremer , Heather Biele , Christopherl Bowlus , University Hospital Zurich , Uc Davis Health , Liver Meeting ,