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GLP-1 receptor agonists 'have changed the playing field' in pediatric MASLD

WASHINGTON — Glucagon-like peptide-1 receptor agonists significantly reduced alanine aminotransferase levels in pediatric metabolic dysfunction-associated steatotic liver disease, especially those with type 2 diabetes, researchers reported. “The study was prompted by my interest in the use of anti-obesity medications in the treatment of MASLD,” Jennifer A. Panganiban, MD,

PhiladelphiaPennsylvaniaUnited statesWashingtonHeather bieleJennifera panganibanSaxenda victozaByrobert stottOzempic wegovyNovo nordiskAstrazenecaNon alcoholic fatty liver disease programPediatric gastroenterology

Weight gain during diet therapy linked to 'worse EoE outcomes' no matter baseline weight

WASHINGTON — Among adults with eosinophilic esophagitis, weight gain while undergoing dietary therapy was associated with poor treatment response, regardless of baseline weight status, according to data presented at Digestive Disease Week. “EoE prevalence has increased alongside the obesity epidemic,” Stephanie A. Borinsky, MD, a gastroenterology fellow in the department of

WashingtonUnited statesByrobert stottStephaniea borinskyHeather bieleUniversity of north carolina school medicineDigestive diseaseNorth carolina school

TRIUMPH: 58% of acute severe UC patients responded 'within 2 days' of starting Xeljanz

WASHINGTON — Nearly 60% of patients with acute severe ulcerative colitis responded to Xeljanz 10 mg twice daily by day 7, with one-third of patients in steroid-free remission by 6 months, according to interim analysis data presented here. “There are few recommended therapies for acute severe UC management given the need for rapidly acting therapies,” Neeraj Narula, MD, MPH,

WashingtonUnited statesHeather bieleNeeraj narulaByrobert stottMcmaster universityPfizerClinic at hamilton health sciencesTriumphHamilton health sciencesModified trueloveWitts severity index

'Unexpectedly high' placebo response derails darvadstrocel for Crohn's perianal fistulas

'Unexpectedly high' placebo response derails darvadstrocel for Crohn's perianal fistulas
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WashingtonUnited statesLaurae raffalsByrobert stottHeather bieleTakeda pharmaceuticalsEuropean unionDigestive diseaseMayo clinic

Survodutide upholds 'promising' reduced liver fat, fibrosis biomarkers in MASH at 28 weeks

Survodutide upholds 'promising' reduced liver fat, fibrosis biomarkers in MASH at 28 weeks
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WashingtonDistrict of columbiaUnited statesArizonaZealand pharmaByrobert stottNaim alkhouriHeather bieleBoehringer ingelheimArizona liver healthDigestive disease week