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The complete sequence and comparative analysis of ape sex chromosomes

Apes possess two sex chromosomes—the male-specific Y chromosome and the X chromosome, which is present in both males and females. The Y chromosome is crucial for male reproduction, with deletions being linked to infertility1. The X chromosome is vital for reproduction and cognition2. Variation in mating patterns and brain function among apes suggests corresponding differences in their sex chromosomes. However, owing to their repetitive nature and incomplete reference assemblies, ape sex chromosomes have been challenging to study. Here, using the methodology developed for the telomere-to-telomere (T2T) human genome, we produced gapless assemblies of the X and Y chromosomes for five great apes (bonobo (Pan paniscus), chimpanzee (Pan troglodytes), western lowland gorilla (Gorilla gorilla gorilla), Bornean orangutan (Pongo pygmaeus) and Sumatran orangutan (Pongo abelii)) and a lesser ape (the siamang gibbon (Symphalangus syndactylus)), and untangled the intricacies of their ....

United States , Wilson Sayres , Iturralde Martinez , Hylobates Symphalangus , Mc Cartney , Mpa Assembly , Repbase Update , Cell Genet , Integrative Genomics , Cancer Res , Improved Pairwise Alignment , Penn State , Acids Res , Annotation Toolkit , Cell Biol , Kosakovsky Pond , Genome Analysis Toolkit ,

Frontiers | Low mutation rate of spontaneous mutants enables detection of causative genes by comparing whole genome sequences

Frontiers | Low mutation rate of spontaneous mutants enables detection of causative genes by comparing whole genome sequences
frontiersin.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from frontiersin.org Daily Mail and Mail on Sunday newspapers.

Toyama Nougi , Ginbouzu Terada , Honzou Zuhu , Clustal Omega , Aizu Nousho , Ito Shoten , Ricexpro Sato , Pavir Ib , Snpeff Cingolani , Development Program For Agriculture , Technology Research Advancement Institution , Cabinet Office , Moonshot Research , Priority Research , Library Prep Reagent Set Biolabs , Japan Society For The Promotion Of Science , Fukushima University , Kyushu University , Bj Springer International Publishing , Illumina Co Ltd , Scientific Research , Plant Mini Kit , Prep Reagent Set , Illumina Hiseq , Genebank Project , New England Biolabs ,

Longitudinal detection of circulating tumor DNA

This article discusses the use of bioinformatics analysis for the longitudinal detection of circulatingtumor DNA. ....

Bsgenome Hsapiens , Collectalignmentsummarymetrics Umi Deduped , Bsgenome Hsapiens Ncbi Grch , Monte Carlo , Exonic Regions , Communications Ltd , Coverage File , Roche Pharmaceuticals , Sponsored Content , Roche Sequencing , Life Sciencenov , Genome Analysis Toolkit , Reference Links , Redhat Linux , Genomic Interval List , Longitudinal Mutation Analysis , Single Nucleotide Polymorphisms , Variant Call Format , Quality Control , Polymerase Chain Reaction , Unique Molecular Identifiers , Device Identification , Image Credit , Illumina Adapter Sequences Document , Random Access Memory , Strand Bias Fisher ,

New blood test revolutionizes early cancer detection in Li-Fraumeni Syndrome patients

Canadian researchers develop a cell-free DNA-based multimodal assay for early cancer detection in patients with Li-Fraumeni Syndrome, a high-cancer-risk condition. The assay outperforms conventional methods, promising more sensitive and less invasive cancer surveillance. ....

Kateryna Kon Shutterstock , Cancer Discovery , Early Cancer Detection , Li Fraumeni Syndrome , Genome Analysis Toolkit , Li Fraumeni Syndrome , Cancer Diagnosis ,

Association of an estrogen-sensitive Pax1-Col11a1-Mmp3 signaling axis with adolescent idiopathic scoliosis

Association of an estrogen-sensitive Pax1-Col11a1-Mmp3 signaling axis with adolescent idiopathic scoliosis
elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.

Hong Kong , United Kingdom , United States , Shriners Hospital For Children , Indiana University , San Diego , Oklahoma City , Purdue University , Rhode Island , Medical College , Texas Scottish Rite Hospital For Children , Baylor College Of Medicine , University Of Massachusetts , Vastra Gotalands Lan , University Of Oklahoma , Yuki Taniguchi , Manabu Ito , Takashi Kaito , Masaya Nakamura , Kenichiro Kakutani , Hiroshi Taneichi , Humancoreexome Beadchip , Lou Soslowsky , Benjamins Richards , Don Conrad , Richard Shindell ,