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Human Identification Analysis Software Market Worth $1204.39 Million by 2032 at CAGR 11.2% As Revealed In New Report

Lucy's Love Bus event raises $97K

To the editor:

Northeast Arc holding annual fundraiser gala

DANVERS — Northeast Arc, a not-for-profit organization that helps children and adults with disabilities or autism become full participants in the community, will host its signature fundraising event, An Evening

Biomanufacturing Viral Detection and Quantification Market Research Details Size, Share and Growth Factors Study

Antisense oligonucleotide therapeutic approach for Timothy syndrome

Timothy syndrome (TS) is a severe, multisystem disorder characterized by autism, epilepsy, long-QT syndrome and other neuropsychiatric conditions1. TS type 1 (TS1) is caused by a gain-of-function variant in the alternatively spliced and developmentally enriched CACNA1C exon 8A, as opposed to its counterpart exon 8. We previously uncovered several phenotypes in neurons derived from patients with TS1, including delayed channel inactivation, prolonged depolarization-induced calcium rise, impaired interneuron migration, activity-dependent dendrite retraction and an unanticipated persistent expression of exon 8A2–6. We reasoned that switching CACNA1C exon utilization from 8A to 8 would represent a potential therapeutic strategy. Here we developed antisense oligonucleotides (ASOs) to effectively decrease the inclusion of exon 8A in human cells both in vitro and, following transplantation, in vivo. We discovered that the ASO-mediated switch from exon