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Johnson & Johnson Submits Application To The European Medicines Agency Seeking Approval Of Subcutaneous Formulation Of RYBREVANT®▼ (Amivantamab) For T...

Johnson & Johnson Submits Application To The European Medicines Agency Seeking Approval Of Subcutaneous Formulation Of RYBREVANT®▼ (Amivantamab) For T...
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United States , Region Flamande , Natasha Leighl , Henar Hevia , Natashab Leighl , American Lung Association , European Medicines Agency Seeking Approval , European Medicines Agency , American Society Of Clinical Oncology Annual Meeting , Princess Margaret Cancer Centre , None Of Janssen Cilag International , Janssen Cilag International , Exchange Commission , American Society Of Clinical Oncology , European Commission , American Society , Clinical Oncology , Annual Meeting , Senior Director , Area Lead , Johnson Innovative Medicine , European Economic Area , Product Characteristics , Innovative Medicine , Private Securities Litigation Reform Act , Annual Report ,

The complete sequence and comparative analysis of ape sex chromosomes

Apes possess two sex chromosomes—the male-specific Y chromosome and the X chromosome, which is present in both males and females. The Y chromosome is crucial for male reproduction, with deletions being linked to infertility1. The X chromosome is vital for reproduction and cognition2. Variation in mating patterns and brain function among apes suggests corresponding differences in their sex chromosomes. However, owing to their repetitive nature and incomplete reference assemblies, ape sex chromosomes have been challenging to study. Here, using the methodology developed for the telomere-to-telomere (T2T) human genome, we produced gapless assemblies of the X and Y chromosomes for five great apes (bonobo (Pan paniscus), chimpanzee (Pan troglodytes), western lowland gorilla (Gorilla gorilla gorilla), Bornean orangutan (Pongo pygmaeus) and Sumatran orangutan (Pongo abelii)) and a lesser ape (the siamang gibbon (Symphalangus syndactylus)), and untangled the intricacies of their ....

United States , Wilson Sayres , Iturralde Martinez , Hylobates Symphalangus , Mc Cartney , Mpa Assembly , Repbase Update , Cell Genet , Integrative Genomics , Cancer Res , Improved Pairwise Alignment , Penn State , Acids Res , Annotation Toolkit , Cell Biol , Kosakovsky Pond , Genome Analysis Toolkit ,

Decoding the interplay between genetic and non-genetic drivers of metastasis

Decoding the interplay between genetic and non-genetic drivers of metastasis
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Al Bakir , Malagoli Tagliazucchi , Vander Velde , Sousae Melo , Us National Library Of Medicine , Transcriptome Core Group , Cancer Analysis Of Whole Genomes Consortium , Core Group , Cancer Analysis , Whole Genomes , Stem Cell , Cancer Genome Atlas , Cell Biol , Metastasis Rev , Cancer Res , Big Bang , Posthumous Evaluation , Advanced Cancer Environment , Acids Res ,

ENHERTU® (fam-trastuzumab deruxtecan-nxki) improved PFS in HER2-low and ultralow

ENHERTU demonstrated statistically significant and clinically meaningful improvement in progression-free survival in HR-positive, HER2-low metastatic breast cancer following one or more lines of. ....

United Kingdom , Israel General , Daiichi Sankyo , Trastuzumab Deruxtecan , Capecitabine Monotherapy , End Results Program , Merck Co Inc , National Cancer Institute , Daiichi Sankyo Inc , Low Metastatic Breast Cancer , Solid Tumors , Positive Locally Advanced , Metastatic Gastric Cancer , Positive Metastatic Breast , Low Metastatic Breast , Mutant Unresectable , Metastatic Solid , Reproductive Potential , Hepatic Impairment , Prescribing Information , Rare Diseases , Cancer Res , Plus Exemestane , Oestrogen Receptor , Negative Advanced Breast , End Results ,

ENHERTU® Demonstrated Statistically Significant and Clinically Meaningful Improvement in Progression-Free Survival in HR Positive, HER2 Low Metastatic Breast Cancer Following One or More Lines of Endocrine Therapy in DESTINY-Breast06 Phase 3 Trial

Daiichi Sankyo and AstraZeneca’s ENHERTU also demonstrated a clinically meaningful progression-free survival improvement in patients with HER2 ultralow expression

Plans for global regulatory. ....

Israel General , Daiichi Sankyo , National Cancer Institute , Daiichi Sankyo Inc , Low Metastatic Breast Cancer , Solid Tumors , Positive Locally Advanced , Metastatic Gastric Cancer , Adverse Reactions , Positive Metastatic Breast Cancer , Mutant Unresectable , Metastatic Solid Tumors , Reproductive Potential , Hepatic Impairment , Prescribing Information , Cancer Res , Stat Facts , Female Breast Cancer , Accessed April , Pathol Transl ,